Probst, Alexander J. and Auerbach, Anna K. and Moissl-Eichinger, Christine (2013) Archaea on Human Skin. PLOS ONE, 8 (6): e65388. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
The recent era of exploring the human microbiome has provided valuable information on microbial inhabitants, beneficials and pathogens. Screening efforts based on DNA sequencing identified thousands of bacterial lineages associated with human skin but provided only incomplete and crude information on Archaea. Here, we report for the first time the quantification and visualization of Archaea from human skin. Based on 16 S rRNA gene copies Archaea comprised up to 4.2% of the prokaryotic skin microbiome. Most of the gene signatures analyzed belonged to the Thaumarchaeota, a group of Archaea we also found in hospitals and clean room facilities. The metabolic potential for ammonia oxidation of the skin-associated Archaea was supported by the successful detection of thaumarchaeal amoA genes in human skin samples. However, the activity and possible interaction with human epithelial cells of these associated Archaea remains an open question. Nevertheless, in this study we provide evidence that Archaea are part of the human skin microbiome and discuss their potential for ammonia turnover on human skin.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AMMONIA-OXIDIZING ARCHAEA; RNA SEQUENCE DATA; METHANOGENIC ARCHAEA; NATURAL COMMUNITIES; HUMAN MICROBIOME; CLEAN ROOMS; BACTERIAL; DIVERSITY; ENVIRONMENTS; ALIGNMENT; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Mikrobiologie (Archaeenzentrum) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Apr 2020 11:58 |
| Last Modified: | 07 Apr 2020 11:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16508 |
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