Akdeniz, Ceren and Schaefer, Axel and Streit, Fabian and Haller, Leila and Wuest, Stefan and Kirsch, Peter and Tost, Heike and Meyer-Lindenberg, Andreas (2017) Sex-Dependent Association of Perigenual Anterior Cingulate Cortex Volume and Migration Background, an Environmental Risk Factor for Schizophrenia. SCHIZOPHRENIA BULLETIN, 43 (4). pp. 925-934. ISSN 0586-7614, 1745-1701
Full text not available from this repository. (Request a copy)Abstract
Migration status is one of the best-established risk factors for schizophrenia. An increase in risk is observed in both first-and second-generation immigrants, with a varying magnitude depending on the ethnic background of the individuals. The underlying mechanisms for the increased risk are only recently coming into focus. A causal role for social stress has been widely proposed, and recent work indicated altered neural stress processing in the perigenual anterior cingulate cortex (pACC) in migrants. Since previous work shows that social stress may lead to enduring changes in the gray matter volume of vulnerable brain regions, we investigated the impact of migration background on brain structure. We studied healthy young adults (N = 124), native Germans and second-generation migrants, using whole-brain structural magnetic resonance imaging. Groups were matched for a broad range of sociodemographic characteristics including age, gender, urban exposure, and education. We found a significant group by sex interaction effect in pACC gray matter volume, which was reduced in males with migration background only. This mirrors previous findings in urban upbringing, another risk factor for schizophrenia. Our results provide convergent evidence for an impact of environmental risk factors linked to schizophrenia on gray matter volume and extend prior data by highlighting the possibility that the pACC structure may be particularly sensitive to the convergent risk factors linked to schizophrenia.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MEDIAL PREFRONTAL CORTEX; EARLY-LIFE STRESS; STRUCTURAL BRAIN ALTERATIONS; GRAY-MATTER VOLUME; MENTAL-HEALTH; SOCIAL SUPPORT; CARDIOVASCULAR-RESPONSES; PSYCHIATRIC-DISORDERS; PSYCHOTIC DISORDERS; SENSITIVE PERIODS; environmental risk; minority status; magnetic resonance imaging; gray matter volume; schizophrenia risk |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie VII (Medizinische Psychologie, Psychologische Diagnostik und Methodenlehre) - Prof. Dr. Brigitte Kudielka |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 20 Feb 2019 15:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1652 |
Actions (login required)
 |
View Item |
