Podocytes Are Nonhematopoietic Professional Antigen-Presenting Cells

Goldwich, Andreas and Burkard, Miriam and Oelke, Martha and Daniel, Christoph and Amann, Kerstin and Hugo, Christian and Kurts, Christian and Steinkasserer, Alexander and Gessner, Andre (2013) Podocytes Are Nonhematopoietic Professional Antigen-Presenting Cells. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 24 (6). pp. 906-916. ISSN 1046-6673,

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Abstract

Podocytes are essential to the structure and function of the glomerular filtration barrier; however, they also exhibit increased expression of MHC class II molecules under inflammatory conditions, and they remove Ig and immune complexes from the glomerular basement membrane (GBM). This finding suggests that podocytes may act as antigen-presenting cells, taking up and processing antigens to initiate specific T cell responses, similar to professional hematopoietic cells such as dendritic cells or macrophages. Here, MHC-antigen complexes expressed exclusively on podocytes of transgenic mice were sufficient to activate CD8+ T cells in vivo. In addition, deleting MHC class II exclusively on podocytes prevented the induction of experimental anti-GBM nephritis. Podocytes ingested soluble and particulate antigens, activated CD4+ T cells, and crosspresented exogenous antigen on MHC class I molecules to CD8+ T cells. In conclusion, podocytes participate in the antigen-specific activation of adaptive immune responses, providing a potential target for immunotherapies of inflammatory kidney diseases and transplant rejection.

Item Type: Article
Uncontrolled Keywords: MHC CLASS-I; T-CELLS; CRESCENTIC GLOMERULONEPHRITIS; VASCULAR ENDOTHELIUM; PROCESSING PATHWAY; NEPHROTIC-SYNDROME; GLOMERULAR INJURY; DENDRITIC CELLS; TRANSGENIC MICE; MOUSE MODEL;
Divisions: Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Depositing User: Dr. Gernot Deinzer
Date Deposited: 08 Apr 2020 08:50
Last Modified: 08 Apr 2020 08:50
URI: https://pred.uni-regensburg.de/id/eprint/16576

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