Wagner, Lysann and Pannicke, Thomas and Rupprecht, Vanessa and Frommherz, Ina and Volz, Cornelia and Illes, Peter and Hirrlinger, Johannes and Jaegle, Herbert and Egger, Veronica and Haydon, Philip G. and Pfrieger, Frank W. and Grosche, Antje (2017) Suppression of SNARE-dependent exocytosis in retinal glial cells and its effect on ischemia-induced neurodegeneration. GLIA, 65 (7). pp. 1059-1071. ISSN 0894-1491, 1098-1136
Full text not available from this repository. (Request a copy)Abstract
Nervous tissue is characterized by a tight structural association between glial cells and neurons. It is well known that glial cells support neuronal functions, but their role under pathologic conditions is less well understood. Here, we addressed this question in vivo using an experimental model of retinal ischemia and transgenic mice for glia-specific inhibition of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-dependent exocytosis. Transgene expression reduced glutamate, but not ATP release from single Muller cells, impaired glial volume regulation under normal conditions and reduced neuronal dysfunction and death in the inner retina during the early stages of ischemia. Our study reveals that the SNARE-dependent exocytosis in glial cells contributes to neurotoxicity during ischemia in vivo and suggests glial exocytosis as a target for therapeutic approaches.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ELECTROGENIC GLUTAMATE UPTAKE; BRAIN ISCHEMIA; MULLER CELLS; RELEASE; ASTROCYTES; ACTIVATION; EXPRESSION; PLASTICITY; MODULATION; MECHANISMS; glutamate; gliotransmitter; ischemia; Muller cell; retina |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Humangenetik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 13 Feb 2019 12:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1658 |
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