Monda, Keri L. and Chen, Gary K. and Taylor, Kira C. and Palmer, Cameron and Edwards, Todd L. and Lange, Leslie A. and Ng, Maggie C. Y. and Adeyemo, Adebowale A. and Allison, Matthew A. and Bielak, Lawrence F. and Chen, Guanjie and Graff, Mariaelisa and Irvin, Marguerite R. and Rhie, Suhn K. and Li, Guo and Liu, Yongmei and Liu, Youfang and Lu, Yingchang and Nalls, Michael A. and Sun, Yan V. and Wojczynski, Mary K. and Yanek, Lisa R. and Aldrich, Melinda C. and Ademola, Adeyinka and Amos, Christopher I. and Bandera, Elisa V. and Bock, Cathryn H. and Britton, Angela and Broeckel, Ulrich and Cai, Quiyin and Caporaso, Neil E. and Carlson, Chris S. and Carpten, John and Casey, Graham and Chen, Wei-Min and Chen, Fang and Chen, Yii-Der I. and Chiang, Charleston W. K. and Coetzee, Gerhard A. and Demerath, Ellen and Deming-Halverson, Sandra L. and Driver, Ryan W. and Dubbert, Patricia and Feitosa, Mary F. and Feng, Ye and Freedman, Barry I. and Gillanders, Elizabeth M. and Gottesman, Omri and Guo, Xiuqing and Haritunians, Talin and Harris, Tamara and Harris, Curtis C. and Hennis, Anselm J. M. and Hernandez, Dena G. and McNeill, Lorna H. and Howard, Timothy D. and Howard, Barbara V. and Howard, Virginia J. and Johnson, Karen C. and Kang, Sun J. and Keating, Brendan J. and Kolb, Suzanne and Kuller, Lewis H. and Kutlar, Abdullah and Langefeld, Carl D. and Lettre, Guillaume and Lohman, Kurt and Lotay, Vaneet and Lyon, Helen and Manson, Joann E. and Maixner, William and Meng, Yan A. and Monroe, Kristine R. and Morhason-Bello, Imran and Murphy, Adam B. and Mychaleckyj, Josyf C. and Nadukuru, Rajiv and Nathanson, Katherine L. and Nayak, Uma and N'Diaye, Amidou and Nemesure, Barbara and Wu, Suh-Yuh and Leske, M. Cristina and Neslund-Dudas, Christine and Neuhouser, Marian and Nyante, Sarah and Ochs-Balcom, Heather and Ogunniyi, Adesola and Ogundiran, Temidayo O. and Ojengbede, Oladosu and Olopade, Olufunmilayo I. and Palmer, Julie R. and Ruiz-Narvaez, Edward A. and Palmer, Nicholette D. and Press, Michael F. and Rampersaud, Evandine and Rasmussen-Torvik, Laura J. and Rodriguez-Gil, Jorge L. and Salako, Babatunde and Schadt, Eric E. and Schwartz, Ann G. and Shriner, Daniel A. and Siscovick, David and Smith, Shad B. and Wassertheil-Smoller, Sylvia and Speliotes, Elizabeth K. and Spitz, Margaret R. and Sucheston, Lara and Taylor, Herman and Tayo, Bamidele O. and Tucker, Margaret A. and Van Den Berg, David J. and Edwards, Digna R. Velez and Wang, Zhaoming and Wiencke, John K. and Winkler, Thomas W. and Witte, John S. and Wrensch, Margaret and Wu, Xifeng and Yang, James J. and Levin, Albert M. and Young, Taylor R. and Zakai, Neil A. and Cushman, Mary and Zanetti, Krista A. and Zhao, Jing Hua and Zhao, Wei and Zheng, Yonglan and Zhou, Jie and Ziegler, Regina G. and Zmuda, Joseph M. and Fernandes, Jyotika K. and Gilkeson, Gary S. and Kamen, Diane L. and Hunt, Kelly J. and Spruill, Ida J. and Ambrosone, Christine B. and Ambs, Stefan and Arnett, Donna K. and Atwood, Larry and Becker, Diane M. and Berndt, Sonja I. and Bernstein, Leslie and Blot, William J. and Borecki, Ingrid B. and Bottinger, Erwin P. and Bowden, Donald W. and Burke, Gregory and Chanock, Stephen J. and Cooper, Richard S. and Ding, Jingzhong and Duggan, David and Evans, Michele K. and Fox, Caroline and Garvey, W. Timothy and Bradfield, Jonathan P. and Hakonarson, Hakon and Grant, Struan F. A. and Hsing, Ann and Chu, Lisa and Hu, Jennifer J. and Huo, Dezheng and Ingles, Sue A. and John, Esther M. and Jordan, Joanne M. and Kabagambe, Edmond K. and Kardia, Sharon L. R. and Kittles, Rick A. and Goodman, Phyllis J. and Klein, Eric A. and Kolonel, Laurence N. and Le Marchand, Loic and Liu, Simin and McKnight, Barbara and Millikan, Robert C. and Mosley, Thomas H. and Padhukasahasram, Badri and Williams, L. Keoki and Patel, Sanjay R. and Peters, Ulrike and Pettaway, Curtis A. and Peyser, Patricia A. and Psaty, Bruce M. and Redline, Susan and Rotimi, Charles N. and Rybicki, Benjamin A. and Sale, Michele M. and Schreiner, Pamela J. and Signorello, Lisa B. and Singleton, Andrew B. and Stanford, Janet L. and Strom, Sara S. and Thun, Michael J. and Vitolins, Mara and Zheng, Wei and Moore, Jason H. and Williams, Scott M. and Ketkar, Shamika and Zhu, Xiaofeng and Zonderman, Alan B. and Kooperberg, Charles and Papanicolaou, George J. and Henderson, Brian E. and Reiner, Alex P. and Hirschhorn, Joel N. and Loos, Ruth J. F. and North, Kari E. and Haiman, Christopher A. (2013) A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. NATURE GENETICS, 45 (6). 690-+. ISSN 1061-4036,
Full text not available from this repository. (Request a copy)Abstract
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 x 10(-11)) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 x 10(-10)). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 x 10(-8)). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 x 10(-7)), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENOME-WIDE ASSOCIATION; MULTILOCUS GENOTYPE DATA; COMMON VARIANTS; POSITIVE SELECTION; SEQUENCE VARIANTS; HUMAN-POPULATIONS; GENETIC-VARIATION; ADULT OBESITY; FTO GENE; RISK; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Apr 2020 08:57 |
| Last Modified: | 08 Apr 2020 08:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16591 |
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