Hellerbrand, Claus (2013) Hepatic stellate cells-the pericytes in the liver. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 465 (6). pp. 775-778. ISSN 0031-6768, 1432-2013
Full text not available from this repository. (Request a copy)Abstract
Hepatic stellate cells (HSCs) are pericytes of liver in the space between parenchymal cells and sinusoidal endothelial cells of the hepatic lobule. HSCs comprise specialized functions such as vitamin A storage, hemodynamic functions, support of liver regeneration, and immunoregulation. In pathological conditions, HSCs transform to an activated myofibroblasts-like phenotype, start to proliferate, and de novo express several proinflammatory and profibrogenic genes. These processes are particularly important in the development of cirrhosis, portal hypertension, and hepatocellular cancer. This review highlights recent findings in understanding the biology of HSCs and discusses the physiological functions of HSCs and the role of activated HSCs in pathophysiology and disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PORTAL-HYPERTENSION; FIBROSIS; Hepatic stellate cell; Myofibroblast; Pericyte; Fibrosis; Immunoregulation; Vasoregulation; Hepatocellular cancer |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 16 Jun 2020 06:28 |
| Last Modified: | 16 Jun 2020 06:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16595 |
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