Baier, Clemens and Schaumburger, Jens and Goetz, Jurgen and Heers, Guido and Schmidt, Thorsten and Grifka, Joachim and Beckmann, Johannes (2013) Bisphosphonates or prostacyclin in the treatment of bone-marrow oedema syndrome of the knee and foot. RHEUMATOLOGY INTERNATIONAL, 33 (6). pp. 1397-1402. ISSN 0172-8172,
Full text not available from this repository. (Request a copy)Abstract
Bone-marrow oedema (BME) represents a reversible but mostly painful increase in interstitial fluid. The exact pathogenetic processes still remain unknown. Treatment options are mainly symptomatic with core decompression as golden standard leading to immediate pain relieve. Recently, it has been shown that intravenous prostacyclin and bisphosphonates are useful in achieving a reduction in BME with a considerable improvement in the accompanying symptoms. We compared the outcome of both intravenously applied prostacyclin (Ilomedin(A (R)), 10 patients) and bisphosphonate (Bondronat(A (R)), 10 patients) in treatment of BME of the knee and foot. We could find a significant improvement of WOMAC score, SF-36 score and VAS 3 months and 1 year after therapeutic intervention in both the prostacyclin and the bisphosphonate group. Concerning the MRI scans in both groups, we found a distinct reduction of BME in 47 % and a complete regression in 40 %. Comparing both groups, the improvement of the scores was greater in the prostacyclin group than in the bisphosphonate group; the difference, however, was not significant. Intravenous bisphosphonates as well as prostacyclin are of efficient therapeutic benefit in treatment of BME with a quicker and greater effect of prostacyclin.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FEMORAL-HEAD; CORE DECOMPRESSION; TRANSIENT OSTEOPOROSIS; ANALOG ILOPROST; DISTRACTION OSTEOGENESIS; NECROSIS; HIP; OSTEONECROSIS; PAMIDRONATE; IBANDRONATE; Bone-marrow oedema; Bisphosphonate; Prostacyclin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Orthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Apr 2020 09:20 |
| Last Modified: | 08 Apr 2020 09:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16599 |
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