Daum, Bertram and Vonck, Janet and Bellack, Annett and Chaudhury, Paushali and Reichelt, Robert and Albers, Sonja-Verena and Rachel, Reinhard and Kuhlbrandt, Werner (2017) Structure and in situ organisation of the Pyrococcus furiosus archaellum machinery. ELIFE, 6: e27470. ISSN 2050-084X,
Full text not available from this repository. (Request a copy)Abstract
The archaellum is the macromolecular machinery that Archaea use for propulsion or surface adhesion, enabling them to proliferate and invade new territories. The molecular composition of the archaellum and of the motor that drives it appears to be entirely distinct from that of the functionally equivalent bacterial flagellum and flagellar motor. Yet, the structure of the archaellum machinery is scarcely known. Using combined modes of electron cryo-microscopy (cryoEM), we have solved the structure of the Pyrococcus furiosus archaellum filament at 4.2 angstrom resolution and visualise the architecture and organisation of its motor complex in situ. This allows us to build a structural model combining the archaellum and its motor complex, paving the way to a molecular understanding of archaeal swimming motion.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IV PILUS; HALOBACTERIUM-SALINARUM; CRYOELECTRON TOMOGRAPHY; MOLECULAR ARCHITECTURE; CHEMORECEPTOR ARRAYS; FLAGELLAR MOTORS; S-LAYER; PROTEIN; CELL; SULFOLOBUS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Mikrobiologie > Prof. Dr. Reinhard Rachel |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 01 Mar 2019 07:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1664 |
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