Chai, Qian and Onder, Lucas and Scandella, Elke and Gil-Cruz, Cristina and Perez-Shibayama, Christian and Cupovic, Jovana and Danuser, Renzo and Sparwasser, Tim and Luther, Sanjiv A. and Thiel, Volker and Ruelicke, Thomas and Stein, Jens V. and Hehlgans, Thomas and Ludewig, Burkhard (2013) Maturation of Lymph Node Fibroblastic Reticular Cells from Myofibroblastic Precursors Is Critical for Antiviral Immunity. IMMUNITY, 38 (5). pp. 1013-1024. ISSN 1074-7613, 1097-4180
Full text not available from this repository. (Request a copy)Abstract
The stromal scaffold of the lymph node (LN) paracortex is built by fibroblastic reticular cells (FRCs). Conditional ablation of lymphotoxin-beta receptor (LT beta R) expression in LN FRCs and their mesenchymal progenitors in developing LNs revealed that LT beta R-signaling in these cells was not essential for the formation of LNs. Although T cell zone reticular cells had lost podoplanin expression, they still formed a functional conduit system and showed enhanced expression of myofibroblastic markers. However, essential immune functions of FRCs, including homeostatic chemokine and interleukin-7 expression, were impaired. These changes in T cell zone reticular cell function were associated with increased susceptibility to viral infection. Thus, myofibroblasic FRC precursors are able to generate the basic T cell zone infrastructure, whereas LT beta R-dependent-maturation of FRCs guarantees full immunocompetence and hence optimal LN function during infection.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CENTRAL-NERVOUS-SYSTEM; T-CELL; DENDRITIC CELLS; KEY REGULATOR; SECONDARY; HOMEOSTASIS; DEFICIENT; ORGANOGENESIS; DIFFERENTIATE; ORGANIZATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Apr 2020 05:43 |
| Last Modified: | 09 Apr 2020 05:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16654 |
Actions (login required)
 |
View Item |
