Carnevali, Luca and Sgoifo, Andrea and Trombini, Mimosa and Landgraf, Rainer and Neumann, Inga D. and Nalivaiko, Eugene (2013) Different Patterns of Respiration in Rat Lines Selectively Bred for High or Low Anxiety. PLOS ONE, 8 (5): UNSP e6451. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
In humans, there is unequivocal evidence of an association between anxiety states and altered respiratory function. Despite this, the link between anxiety and respiration has been poorly evaluated in experimental animals. The primary objective of the present study was to investigate the hypothesis that genetic lines of rats that differ largely in their anxiety level would display matching alterations in respiration. To reach this goal, respiration was recorded in high-anxiety behavior (HAB, n = 10) and low-anxiety behavior (LAB, n = 10) male rats using whole-body plethysmography. In resting state, respiratory rate was higher in HABs (85 +/- 2 cycles per minute, cpm) than LABs (67 +/- 2 cpm, p < 0.05). During initial testing into the plethysmograph and during a restraint test, HAB rats spent less time at high-frequency sniffing compared to LAB rats. In addition, HAB rats did not habituate in terms of respiratory response to repetitive acoustic stressful stimuli. Finally, HAB rats exhibited a larger incidence of sighs during free exploration of the plethysmograph and under stress conditions. We conclude that: i) HAB rats showed respiratory changes (elevated resting respiratory rate, reduced sniffing in novel environment, increased incidence of sighs, and no habituation of the respiratory response to repetitive stimuli) that resemble those observed in anxious and panic patients, and ii) respiratory patterns may represent a promising way for assessing anxiety states in preclinical studies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEONATAL MATERNAL SEPARATION; HYPOXIC VENTILATORY RESPONSE; PANIC DISORDER PATIENTS; TRAIT ANXIETY; ANIMAL-MODEL; AWAKE RAT; BEHAVIOR; NEUROENDOCRINE; IRREGULARITY; HYPERVENTILATION; |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Apr 2020 05:58 |
| Last Modified: | 09 Apr 2020 05:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16666 |
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