Schlitt, Hans J. and Jonas, Sven and Ganten, Tom M. and Grannas, Gerrit and Moench, Christian and Rauchfuss, Falk and Obed, Aiman and Tisone, Giuseppe and Pinna, Antonio D. and Gerunda, Giorgio E. and Beckebaum, Susanne (2013) Effects of mycophenolate mofetil introduction in liver transplant patients: results from an observational, non-interventional, multicenter study (LOBSTER). CLINICAL TRANSPLANTATION, 27 (3). pp. 368-378. ISSN 0902-0063,
Full text not available from this repository. (Request a copy)Abstract
The benefits of calcineurin inhibitor (CNI)-sparing regimens on renal function following liver transplantation (LT) have been demonstrated in clinical studies. This observational study assessed the real-life effects of mycophenolate mofetil (MMF) introduction in LT patients. Four hundred and ninety-seven patients in whom MMF was introduced according to local standards or clinical considerations were entered. Patients were grouped by time between transplantation and start of MMF (start of study): Group A (n=263): 6d; Group B (n=64): >6d to 1month; Group C (n=74): >1month to 1yr; and Group D (n=96): >1yr. CNI sparing occurred in all groups, particularly in Groups C and D. Mean MMF doses at 12months were 1202.7, 1363.5, 1504.7, and 1578.1mg/d, respectively, in Groups A-D. At introduction of MMF, median glomerular filtration rate was 73.3, 81.7, 62.7, and 53.7mL/min/1.73m2 in Groups A-D. At 12months, this decreased to 66mL/min/1.73m2 in Groups A and B, remained stable in Group C, and increased in Group D (64.8mL/min/1.73m2). Serious adverse drug reactions were lowest in Group D. In conclusion, MMF with a subsequent decrease in CNI was well tolerated and improved renal function even years after transplantation. A more forceful MMF dosing strategy with greater CNI sparing may further improve renal function.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LONG-TERM SURVIVAL; RENAL DYSFUNCTION; CALCINEURIN INHIBITORS; CARDIOVASCULAR RISK; CYCLOSPORINE; RECIPIENTS; IMMUNOSUPPRESSION; TACROLIMUS; NEPHROTOXICITY; COMBINATION; calcineurin inhibitor; liver transplantation; mycophenolate mofetil; renal function |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Apr 2020 07:20 |
| Last Modified: | 09 Apr 2020 07:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16688 |
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