Johannsen, Stephan and Berberich, Christina and Metterlein, Thomas and Roth, Cosima and Reiners, Karlheinz and Roewer, Norbert and Schuster, Frank (2013) Screening test for malignant hyperthermia in patients with persistent hyperCKemia: A pilot study. MUSCLE & NERVE, 47 (5). pp. 677-681. ISSN 0148-639X,
Full text not available from this repository. (Request a copy)Abstract
Introduction: Persistently elevated serum creatine kinase (CK) is frequently associated with predisposition to malignant hyperthermia (MH). We investigated whether a minimally invasive metabolic test is suitable to diagnose MH susceptibility among patients with hyperCKemia. Methods: Thirty-nine participants were included: 10 were MH susceptible (MHS); 21 MH were non-susceptible (MHN); and 8 had MHN with persistent hyperCKemia >500 U/L. Microdialysis probes were inserted into the vastus lateralis muscle, and halothane or caffeine was injected via an attached microtubing catheter. Lactate concentrations in dialysis samples were measured spectrophotometrically. Results: Baseline lactate did not differ between the groups. After local application of halothane or caffeine, a significant lactate increase was detected only in the MHS group. Conclusions: Test results were not influenced by hyperCKemia. To avoid risks and complications of a surgical muscle biopsy this microdialysis test might be a useful screening tool for MH susceptibility among patients with persistent CK elevation. Muscle Nerve 47: 677681, 2013
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CREATINE-KINASE LEVELS; VITRO CONTRACTURE TEST; HYPER-CK-EMIA; METABOLIC TEST; INTRAMUSCULAR INJECTION; IDIOPATHIC HYPERCKEMIA; MUSCLE BIOPSY; SUSCEPTIBILITY; HALOTHANE; CAFFEINE; halothane; hyperCKemia; malignant hyperthermia; metabolic test; microdialysis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Apr 2020 13:08 |
| Last Modified: | 15 Apr 2020 13:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16729 |
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