Mueller, Maximilian and Agaimy, Abbas and Zenk, Johannes and Ettl, Tobias and Iro, Heinrich and Hartmann, Arndt and Seliger, Barbara and Schwarz, Stephan (2013) The prognostic impact of human leukocyte antigen (HLA) class I antigen abnormalities in salivary gland cancer. A clinicopathological study of 288 cases. HISTOPATHOLOGY, 62 (6). pp. 847-859. ISSN 0309-0167,
Full text not available from this repository. (Request a copy)Abstract
Aims To study abnormalities of proteins of the major histocompatibility complex class I in a series of 288 salivary gland carcinomas, and to correlate findings with patients' overall survival (OS). Methods and results Protein expression of human leukocyte antigen (HLA)-A, heavy chain (HC)-10, 2-microglobulin, low molecular weight polypeptides (LMP) 2 and 7, transporters associated with antigen processing (TAP) 1 and 2, calnexin, calreticulin, endoplasmic reticulum (ER) p57 and tapasin was evaluated by immunohistochemistry and semiquantitatively analyzed. As compared with normal salivary gland tissue, HLA-A, LMP7, TAP2 and HLA class I were significantly down-regulated in salivary gland carcinomas, whereas 2-microglobulin, calnexin, LMP2, and TAP1 were upregulated. Expression of calreticulin, ERp57 and tapasin was unaltered. In univariate KaplanMeier analyses, low expression of LMP7 (P=0.005) and high expression of 2-microglobulin (P=0.028), HLA-A (P<0.001), TAP1 (P=0.01), and tapasin (P<0.001) were significantly associated with shorter OS. In multivariate analysis incorporating tumour stage, nodal/distant metastasis, and grade, HLA-A (P=0.014), LMP7 (P=0.033), and tapasin (P=0.024), as well as distant metastasis (P=0.012) and high tumour grade (P<0.001), remained statistically significant. Conclusion The prognostic influence of up-regulated HLA-A and tapasin and down-regulated LMP7 may provide a rationale for targeting these specific components of the antigen processing and presentation pathway in salivary gland carcinomas.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SQUAMOUS-CELL CARCINOMA; DOWN-REGULATION; MONOCLONAL-ANTIBODIES; PROCESSING MACHINERY; COLORECTAL-CANCER; IMMUNE ESCAPE; HUMAN TUMORS; EXPRESSION; ASSOCIATION; DEFECTS; HLA class I; immune escape; immunohistochemistry; prognosis; salivary gland cancer |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Apr 2020 13:24 |
| Last Modified: | 15 Apr 2020 13:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16740 |
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