Pischke, Sven and Hardtke, Svenja and Bode, Ulrike and Birkner, Stephan and Chatzikyrkou, Christos and Kauffmann, Wolfgang and Bara, Christoph L. and Gottlieb, Jens and Wenzel, Juergen and Manns, Michael P. and Wedemeyer, Heiner (2013) Ribavirin treatment of acute and chronic hepatitis E: a single-centre experience. LIVER INTERNATIONAL, 33 (5). pp. 722-726. ISSN 1478-3223, 1478-3231
Full text not available from this repository. (Request a copy)Abstract
Background The role of ribavirin for treatment of severe acute or chronic hepatitis E virus (HEV) infection is not well defined. Aims To investigate the applicability and efficacy of ribavirin therapy in acute and chronic HEV infections within a large single-centre cohort. Materials & Methods Clinical courses of forty-four German HEV-infected individuals were analysed. Results In a prospective case series, we observed spontaneous recovery from acute symptomatic HEV-infection in 10/11 immunocompetent individuals. Ribavirin therapy was initiated in one patient with severe acute HEV-genotype-1e infection who rapidly improved liver function and cleared HEV. Of 15 organ transplant recipients with prolonged HEV viraemia, reduction in immunosuppression led to HEV-clearance in three patients, while ribavirin therapy was initiated in 11 subjects. A rapid response with undetectable HEV-RNA occurred in nine subjects. One patient died after experiencing a virological breakthrough associated with ribavirin dose reduction because of severe anaemia. Discussion Ribavirin is a safe treatment option for HEV infections. However, the optimal dose of ribavirin for the treatment of chronic hepatitis E remains to be determined as treatment failure may occur.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | E VIRUS-INFECTION; LIVER-TRANSPLANT RECIPIENTS; THERAPY; acute liver failure; hepatitis E; HEV; ribavirin; transplantation; treatment |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Apr 2020 06:26 |
| Last Modified: | 16 Apr 2020 06:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16782 |
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