Wimmer, Nadin and Heigl, Ulrike and Klingseisen, Laura and Schneider-Brachert, Wulf and Hehlgans, Thomas (2013) Lymphotoxin-beta receptor signalling regulates cytokine expression via TRIM30 alpha in a TRAF3-dependent manner. MOLECULAR IMMUNOLOGY, 54 (1). pp. 40-47. ISSN 0161-5890,
Full text not available from this repository. (Request a copy)Abstract
Our earlier studies indicated that activation of the lymphotoxin beta receptor (LT beta R) by T cell derived LT alpha(1)beta(2) regulates inflammatory cytokine expression. While characterizing the cellular and molecular mechanisms responsible for the down regulation of the inflammatory reaction after LT beta R stimulation we were able to identify the specific induction of TRIM30 alpha expression as a result of LT beta R signalling in mouse macrophages. Furthermore, we could demonstrate that LT beta R activation in these cells results in the down regulation of pro-inflammatory cytokine (e.g. TNF and IL-6) and mediator expression upon TLR4 and TLR9 re-stimulation, demonstrating that LT beta R activation on mouse macrophages dampens pro-inflammatory cytokine and mediator expression. Thus, LT beta R signalling renders macrophages hypo-responsive to subsequent stimulation with TLR ligands. The observation of an LT beta R-mediated TLR-tolerance in the human monocyte cell line THP-1 suggests that similar signalling mechanisms seem to exist in human cells. Signalling pathway analysis clearly demonstrated that LT beta R-induced TRIM30 alpha expression is mediated by an I kappa B alpha-dependent signalling pathway. Furthermore, the LT beta R-induced TRIM30 alpha expression seems to be TRAF3 dependent. Our data suggest that LT beta R activation on mouse macrophages is involved in the control of pro-inflammatory cytokine and mediator expression by activation of a signalling pathway that controls exacerbating inflammatory cytokine production. (C) 2012 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NF-KAPPA-B; INDUCED INTESTINAL INFLAMMATION; GENE-EXPRESSION; DENDRITIC CELLS; ACTIVATION; TOLERANCE; TRAF3; SPECIFICITY; HOMEOSTASIS; ADAPTERS; LT beta R signalling; Cytokine expression; Inflammation; TRIM30 alpha; TRAF3 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Apr 2020 07:46 |
| Last Modified: | 16 Apr 2020 07:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16795 |
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