Lask, Assaf and Ophir, Eran and Or-Geva, Noga and Cohen-Fredarow, Adva and Afik, Ran and Eidelstein, Yaki and Reich-Zeliger, Shlomit and Nathansohn, Bar and Edinger, Matthias and Negrin, Robert S. and Hagin, David and Reisner, Yair (2013) A new approach for eradication of residual lymphoma cells by host nonreactive anti-third-party central memory CD8 T cells. BLOOD, 121 (15). pp. 3033-3040. ISSN 0006-4971,
Full text not available from this repository. (Request a copy)Abstract
Generation of T cells endowed with graft-versus-leukemia (GVL) and depleted of graft-versus-host (GVH) activity represents a highly desirable goal in bone marrow transplantation (BMT). Here, we demonstrate that donor anti-third-party CD8 T cells with central memory phenotype (Tcm) exhibit marked GVL reactivity through a unique T-cell receptor-independent mechanism. Thus, in a residual disease mouse model, Tcm therapy following autologous BMT led to significant survival prolongation, with 30% to 40% of the treated mice displaying long-term tumor-free survival. A more impressive finding was that infusion of donor Tcm in an allogeneic model rapidly eliminated residual lymphoma cells and led to long-term survival of 100% in the absence of GVH disease. Collectively, the strong GVL reactivity of anti-third-party Tcm, coupled with their demonstrated enhancement of bone marrow allografting, suggests that the use of Tcm therapy in conjunction with allogeneic T-cell-depleted BMT could be of particular benefit in patients with B-cell malignancies who cannot tolerate intensive myeloablative conditioning.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NON-HODGKINS-LYMPHOMA; HIGH-DOSE THERAPY; FOLLICULAR LYMPHOMA; TRANSPLANTATION; DISEASE; MALIGNANCIES; EXPRESSION; ALLOGRAFTS; TOLERANCE; RITUXIMAB; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Apr 2020 05:43 |
| Last Modified: | 17 Apr 2020 05:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16827 |
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