Walther, Neele and Ulrich, Antje and Vockerodt, Martina and von Bonin, Frederike and Klapper, Wolfram and Meyer, Katharina and Eberth, Sonja and Pukrop, Tobias and Spang, Rainer and Truemper, Lorenz and Kube, Dieter (2013) Aberrant Lymphocyte Enhancer-Binding Factor 1 Expression Is Characteristic for Sporadic Burkitt's Lymphoma. AMERICAN JOURNAL OF PATHOLOGY, 182 (4). pp. 1092-1098. ISSN 0002-9440,
Full text not available from this repository. (Request a copy)Abstract
Burkitt's Lymphoma (BL) is a highly malignant, aggressive non-Hodgkin's lymphoma derived from germinal center B cells. Recently, global gene expression profiling of patient samples Led to a molecular definition of BL with lymphocyte enhancer binding factor 1 (LEF1) as a signature gene. Herein, we report the expression of nucleic LEF1 in 15 of 18 patients with BL and the identification of LEF1 target genes. Germinal center B cells were devoid of detectable nuclear LEF1 expression, as were mantle cell lymphoma (0 of 5), marginal zone lymphoma (0 of 6), follicular lymphoma (0 of 12), and diffuse large B-cell lymphoma (1 of 31). Whole-genome gene expression profiling after transient knockdown of LEF1 in BL cell Lines identified new LEF1 target genes; these LEF1 targets are enriched with genes associated with cancers. The expression of LEF1 and LEF1-regulated genes in primary BL suggests that LEF1 is not only aberrantly expressed but also transcriptionally active. This study supports a functionally important role for LEF1 and its target genes in BLs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | WNT-SIGNALING PATHWAY; ACUTE LYMPHOBLASTIC-LEUKEMIA; B-CELL LYMPHOMAS; MULTIPLE-MYELOMA; ALPHA-ENHANCER; PROLIFERATION; ACTIVATION; APOPTOSIS; PROFILES; PROTEIN; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Apr 2020 08:00 |
| Last Modified: | 17 Apr 2020 08:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16858 |
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