Kopp, Christoph and Beyer, Christian and Linz, Peter and Dahlmann, Anke and Hammon, Matthias and Jantsch, Jonathan and Neubert, Patrick and Rosenhauer, Daniela and Mueller, Dominik N. and Cavallaro, Alexander and Eckardt, Kai-Uwe and Schett, Georg and Luft, Friedrich C. and Uder, Michael and Distler, Joerg H. W. and Titze, Jens (2017) Na+ deposition in the fibrotic skin of systemic sclerosis patients detected by Na-23-magnetic resonance imaging. RHEUMATOLOGY, 56 (4). pp. 556-560. ISSN 1462-0324, 1462-0332
Full text not available from this repository. (Request a copy)Abstract
Objective. Skin fibrosis is the predominant feature of SSc and arises from excessive extracellular matrix deposition. Glycosaminoglycans are macromolecules of the extracellular matrix, which facilitate Na+ accumulation in the skin. We used Na-23-MRI to quantify Na+ in skin. We hypothesized that skin Na+ might accumulate in SSc and might be a biomarker for skin fibrosis. Methods. In this observational case-control study, skin Na+ was determined by Na-23-MRI using a Na+ volume coil in 12 patients with diffuse cutaneous SSc and in 21 control subjects. We assessed skin fibrosis by the modified Rodnan skin score prior to Na-23-MRI and on follow-up 12 months later. Results.Na-23-MRI demonstrated increased Na+ in the fibrotic skin of SSc patients compared with skin from controls [mean (s.d.): 27.2 (5.6) vs 21.4 (5.3) mmol/l, P < 0.01]. Na+ content was higher in fibrotic than in non-fibrotic SSc skin [26.2 (4.8) vs 19.2 (3.4) mmol/l, P < 0.01]. Furthermore, skin Na+ amount was correlated with changes in follow-up modified Rodnan skin score (R-2 = 0.68). Conclusions.Na-23-MRI detected increased Na+ in the fibrotic SSc skin; high Na+ content was associated with progressive skin disease. Our findings provide the first evidence that Na-23-MRI might be a promising tool to assess skin Na+ and thereby predict progression of skin fibrosis in SSc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OSMOTICALLY INACTIVE NA+; TISSUE SODIUM; CLASSIFICATION; CRITERIA; DISEASE; STORAGE; GROWTH; systemic sclerosis; fibrosis; skin Na+; Na-23-MRI; extracellular matrix |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:00 |
| Last Modified: | 20 Feb 2019 13:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/169 |
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