Bergmann, I. and Goehner, A. and Crozier, T. A. and Hesjedal, B. and Wiese, C. H. and Popov, A. F. and Bauer, M. and Hinz, J. M. (2013) Surgical pleth index-guided remifentanil administration reduces remifentanil and propofol consumption and shortens recovery times in outpatient anaesthesia. BRITISH JOURNAL OF ANAESTHESIA, 110 (4). pp. 622-628. ISSN 0007-0912, 1471-6771
Full text not available from this repository. (Request a copy)Abstract
Background. The surgical pleth index (SPI) is an index based on changes in plethysmographic characteristics that correlate with the balance between the sympathetic and parasympathetic nervous system. It has been proposed as a measure of the balance between nociception and anti-nociception. The goal of this study was to test whether it could be used to titrate remifentanil in day-case anaesthesia. Methods. A total of 170 outpatients were given total i.v. anaesthesia with propofol and remifentanil. The patients were randomized to have the remifentanil dose either adjusted according to the SPI (SPI group) or to clinical parameters (control group). The propofol dose was adjusted according to entropy in both groups. The consumption of anaesthetic drugs, recovery times, and complications were compared. Results. The mean [standard deviation (SD)] remifentanil and propofol infusion rates in the SPI and control groups were 0.06 (0.04) vs 0.08 (0.05) mu g kg(-1) min(-1) and 6.0 (2.1) vs 7.5 (2.2) mg kg(-1) h(-1), respectively (both P < 0.05). The mean (SD) times to eye opening were -0.08 (4.4) and 3.5 (4.3) min and to extubation were 1.2 (4.4) and 4.4 (4.5) min in the SPI and control groups, respectively (both P < 0.05). There was no difference between the groups with regard to satisfaction with the anaesthetic or intensity of postoperative pain. No patient reported intraoperative awareness. Conclusions. Adjusting the remifentanil dosage according to the SPI in outpatient anaesthesia reduced the consumption of both remifentanil and propofol and resulted in faster recovery.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BISPECTRAL INDEX; STRESS INDEX; GENERAL-ANESTHESIA; PATIENT RESPONSIVENESS; RESPONSES; ENTROPY; SURGERY; SEVOFLURANE; MANAGEMENT; ANALGESIA; anaesthesia, depth; EEG; SPI/surgical pleth index; stress; surgery, day-case; sympathetic nervous system |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Apr 2020 07:03 |
| Last Modified: | 20 Apr 2020 07:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16923 |
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