Schoenberger, Katharina and Riedel, Christina and Rueckinger, Simon and Mansmann, Ulrich and Jilg, Wolfgang and Kries, Ruediger v. (2013) Determinants of Long-term Protection After Hepatitis B Vaccination in Infancy: A Meta-analysis. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 32 (4). pp. 307-313. ISSN 0891-3668, 1532-0987
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Background: The duration of protection after hepatitis B vaccination in early infancy is unclear and may be related to vaccination schedule, dosage, vaccine type and population characteristics. Factors potentially influencing waning immunity were assessed. Methods: A systematic review was performed. The main outcomes were prevalence of anti-hepatits B antibodies >= 10 mIU/mL after primary or booster vaccination. Factors potentially influencing protection were assessed in an adjusted random-effects meta-analysis model by age for both outcomes. Results of both meta-analyses were combined in a prognostic model. Results: Forty-six studies reporting on the anti-hepatits B antibodies >= 10 mIU/mL 5 to 20 years after primary immunization and 29 on booster response were identified. The adjusted meta-analyses identified maternal carrier status (odds ratio [OR]: 2.37 [1.11; 5.08]), lower vaccine dosage than presently recommended (OR: 0.14 [0.06; 0.30]) and gap time between last and preceding dose of the primary vaccine series (OR: 0.44 [0.22; 0.86]) as determinants for persistence of anti-hepatits B antibodies >= 10. A lower vaccine dosage was also associated with failure to respond to booster (OR: 0.20 [0.10; 0.38]). The prognostic model predicted long-term protection of 90% [77%; 100%] at the age of 17 years for offspring of noncarrier mothers vaccinated with a presently recommended dose and vaccination schedule. Conclusions: Based on meta-analyses, predictors of waning immunity after hepatitis B vaccination in infancy could be identified. A prognostic model for long-term protection after hepatitis B vaccination in infancy was developed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 12-YEAR FOLLOW-UP; ANTI-HBS; ANAMNESTIC RESPONSE; SURFACE ANTIBODY; IMMUNE MEMORY; CHILDREN; BOOSTER; EFFICACY; PERSISTENCE; IMMUNIZATION; hepatitis B; infant vaccination; booster; long-term protection; determinants of protection |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Apr 2020 08:35 |
| Last Modified: | 20 Apr 2020 08:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16941 |
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