Kramer, Maxi and Heussner, Pia and Herzberg, Philipp Y. and Andree, Holger and Hilgendorf, Inken and Leithaeuser, Malte and Junghanss, Christian and Freund, Mathias and Wolff, Daniel (2013) Validation of the grip test and human activity profile for evaluation of physical performance during the intermediate phase after allogeneic hematopoietic stem cell transplantation. SUPPORTIVE CARE IN CANCER, 21 (4). pp. 1121-1129. ISSN 0941-4355, 1433-7339
Full text not available from this repository. (Request a copy)Abstract
The aims of the presented study were to validate tools evaluating physical functioning (PF) after allogeneic hematopoietic stem cell transplantation (alloHSCT) and to analyze the impact of the clinical course on PF. Forty patients undergoing alloHSCT were enrolled in a prospective trial which included evaluation of muscle strength (grip test, CITEC dynamometer), endurance (2-min walk test), anxiety and depression (Hospital Anxiety and Depression Scale), fatigue (Modified Fatigue Impact Scale and Brief Fatigue Inventory), and physical activity (Human Activity Profile-HAP) before (t1) and 1 (t2) and 3 (t3) months after alloHSCT. At t2, all patients showed a 6 % (p = 0.02) loss of muscle strength which was higher in patients with acute graft-versus-host disease (aGVHD) (12 %). While patients without aGVHD recovered at t3, the loss of muscle strength was progressive in patients with aGVHD. The grip test results correlated with the results of detailed measurement of muscle strength by CITEC dynamometer (r = 0.4-0.8, p = 0.05-0.001). Moreover, the HAP scores correlated with physical performance. The results demonstrate that loss of PF occurs during the first month followed by a regain during the subsequent 2 months in the absence of aGVHD. The HAP and the grip test may serve as surrogate marker for the strength loss in the course of aGVHD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | QUALITY-OF-LIFE; SKELETAL-MUSCLE STRENGTH; VERSUS-HOST-DISEASE; STEROID MYOPATHY; EXERCISE; FATIGUE; THERAPY; Allogeneic hematopoietic stem cell transplantation; Human activity profile; Graft-versus-host disease; Quality of life; Grip test |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Apr 2020 05:07 |
| Last Modified: | 23 Apr 2020 05:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/16960 |
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