Di Benedetto, B. and Rupprecht, R. (2013) Targeting Glia Cells: Novel Perspectives for the Treatment of Neuropsychiatric Diseases. CURRENT NEUROPHARMACOLOGY, 11 (2). pp. 171-185. ISSN 1570-159X, 1875-6190
Full text not available from this repository. (Request a copy)Abstract
Neuropsychiatric disorders are devastating mental illnesses with a high economic burden. The additional morbidity associated with social issues that arises along with the course of these diseases increases the need for a clear understanding of their etiopathogenesis to allow an implementation of novel pharmacological strategies. Yet a poor knowledge about interactions occurring at the glia-neuron interface in health and disease still hampers innovative discoveries, despite the fact that glia cells have been long described to actively participate in the regulation of brain circuits. The purpose of this review was to collect the scattered literature on the involvement of glia cells in neuropsychiatric disorders and to describe how also these cells besides neurons might be responsive to current pharmacological interventions. We hope thereby to offer alternative approaches for investigations that may open avenues to search for new potential targets for drug discovery.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MAJOR DEPRESSIVE DISORDER; BIPOLAR-I DISORDER; BRAIN-DEVELOPMENT; OLIGODENDROCYTE DIFFERENTIATION; SYNAPTIC COMMUNICATION; CNS SYNAPTOGENESIS; MOOD STABILIZERS; APOLIPOPROTEIN-E; CEREBRAL-CORTEX; AMPA RECEPTORS; Astrocytes; microglia; neuropsychiatric disorders; oligodendrocytes; pharmacotherapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Apr 2020 13:12 |
| Last Modified: | 23 Apr 2020 13:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17010 |
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