Schroll, Stephan and Sebah, Daniela and Wagner, Michael and Popara, Viktoria and Pfeifer, Michael and Blumberg, Friedrich (2013) Improvement of exercise capacity in monocrotaline-induced pulmonary hypertension by the phosphodiesterase-5 inhibitor Vardenafil. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 186 (1). pp. 61-64. ISSN 1569-9048, 1878-1519
Full text not available from this repository. (Request a copy)Abstract
Vardenafil, a phosphodiesterase-5 inhibitor, is approved for the therapy of erectile dysfunction. However, in contrast to Sildenafil and Tadalafil, little is known about its effects on pulmonary hypertension. Four weeks after monocrotaline-administration rats exhibited a significant increase in right ventricular pressure (RVSP, 94 mmHg vs. 25 mmHg; p =0.001) right ventricular weight (right ventricle/left ventricle + septum, 59 vs. 23; p =0.001) and pulmonary vascular remodeling (medial wall area 104% vs. 66%; p < 0.05) as compared to controls, with a corresponding reduction in exercise capacity (% from baseline value: 67%; p <0.05). Vardenafil treatment resulted in decreased RVSP (56 mmHg vs. 95 mmHg; p = 0.008), right ventricular weight (41 vs. 59; p = 0.013), pulmonary vascular remodeling (medial wall area 64% vs. 104%; p <0.05) and a significant better exercise capacity (% from baseline value: 84% vs. 67%; p <0.05) compared to monocrotaline only treated animals. In conclusion, Vardenafil exerts beneficial effects on monocrotaline-induced pulmonary hypertension in rats. Whether it is a treatment option for patients with pulmonary hypertension needs to be elucidated. (C) 2012 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ARTERIAL-HYPERTENSION; SILDENAFIL; THERAPY; RATS; TADALAFIL; PDE5; Pulmonary hypertension; Vardenafil; Exercise capacity; Monocrotaline |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Apr 2020 10:23 |
| Last Modified: | 23 Apr 2020 10:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17013 |
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