Beckmann, Johannes and Knoedl, Matthias and Bauser, Eva and Tingart, Markus and Grifka, Joachim and Straub, Rainer H. (2013) Loss of sympathetic nerve fibers in vital intertrochanteric bone cylinders lateral to osteonecrosis of the femoral head. JOINT BONE SPINE, 80 (2). pp. 188-194. ISSN 1297-319X,
Full text not available from this repository. (Request a copy)Abstract
Objectives: Although etiology in osteonecrosis of the femoral head mainly depends on alterations of bone blood flow, vasoregulatory nerve fibers of the sympathetic and sensory nervous system have never been investigated in bone of osteonecrosis patients. This study aimed to demonstrate density of sympathetic and sensory nerve fibers in femoral head and, for comparison, adjacent periosteum, and synovium of the hip joint in patients with osteonecrosis. Methods: Immunofluorescence staining techniques were applied using specific nerve fiber markers. A total of 10 patients with early femoral head osteonecrosis (ARCO I-II), 10 with late femoral head osteonecrosis (ARCO III-IV), and 10 patients with osteoarthritis of the hip were investigated. Results: In the bone of the femoral head, density of sympathetic nerve fibers was lower in early and late osteonecrosis compared to osteoarthritis. There was a marked preponderance of sympathetic over sensory nerve fibers in bone of osteoarthritis patients, which was opposite in early and late femoral head osteonecrosis. In periosteum, density of sympathetic nerve fibers was similar in all three groups but density of sensory nerve fibers and cellularity were higher in early osteonecrosis compared to the other two groups. Discussion/Conclusions: Due to the different affinity of norepinephrine for alpha-adrenoceptors (high affinity) and beta-adrenoceptors (low affinity), the loss of sympathetic nerve fibers relative to sensory nerve fibers in femoral head osteonecrosis might change the femoral head blood flow (towards alpha-adrenergic vasoconstriction). Higher density of sensory nerve fibers and cellularity in periosteum might indicate an inflammatory response in early osteonecrosis. (C) 2012 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENE-RELATED PEPTIDE; SUBSTANCE-P; RHEUMATOID-ARTHRITIS; SYNOVIAL TISSUE; NONTRAUMATIC OSTEONECROSIS; INNERVATION; INFLAMMATION; MECHANISMS; CELLS; RATS; Osteonecrosis of the femoral head; Osteoarthritis of the hip; Sensory nerve fibers; Sympathetic nerve fibers |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Orthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Apr 2020 11:36 |
| Last Modified: | 23 Apr 2020 11:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17039 |
Actions (login required)
 |
View Item |
