Nemeth, Attila and Perez-Fernandez, Jorge and Merkl, Philipp and Hamperl, Stephan and Gerber, Jochen and Griesenbeck, Joachim and Tschochner, Herbert (2013) RNA polymerase I termination: Where is the end? BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 1829 (3-4). pp. 306-317. ISSN 1874-9399, 0006-3002
Full text not available from this repository. (Request a copy)Abstract
The synthesis of ribosomal RNA (rRNA) precursor molecules by RNA polymerase I (Poll) terminates with the dissociation of the protein-DNA-RNA ternary complex. Based on in vitro results the mechanism of Pol I termination appeared initially to be rather conserved and simple until this process was more thoroughly re-investigated in vivo. A picture emerged that Poll termination seems to be connected to co-transcriptional processing, re-initiation of transcription and, possibly, other processes downstream of Pol I transcription units. In this article, our current understanding of the mechanism of Poll termination and how this process might be implicated in other biological processes in yeast and mammals is summarized and discussed. This article is part of a Special Issue entitled: Transcription by Odd Pals. (C) 2012 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FACTOR TTF-I; TRANSCRIPT-RELEASE FACTOR; PRE-RIBOSOMAL-RNA; DNA-BINDING PROTEIN; REPLICATION FORK BLOCKING; SACCHAROMYCES-CEREVISIAE; XENOPUS-LAEVIS; YEAST RDNA; SCHIZOSACCHAROMYCES-POMBE; ELONGATION COMPLEX; Nucleolus; rRNA processing; rDNA chromatin; Aging; rDNA stability; Transcript release |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Herbert Tschochner |
| Depositing User: | Petra Gürster |
| Date Deposited: | 27 May 2020 10:18 |
| Last Modified: | 27 May 2020 10:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17046 |
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