Grummt, Ingrid and Laengst, Gernot (2013) Epigenetic control of RNA polymerase I transcription in mammalian cells. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 1829 (3-4). pp. 393-404. ISSN 1874-9399, 0006-3002
Full text not available from this repository. (Request a copy)Abstract
rRNA synthesis is regulated by genetic and epigenetic mechanisms. Epigenetic states are metastable, changing in response to appropriate signals, thereby modulating transcription in vivo. The establishment, maintenance and reversal of epigenetic features are fundamental for the cell's ability to 'remember' past events, to adapt to environmental changes or developmental cues and to propagate this information to the progeny. As packaging into chromatin is critical for the stability and integrity of repetitive DNA, keeping a fraction of rRNA genes in a metastable heterochromatic conformation prevents aberrant exchanges between repeats, thus safeguarding nucleolar structure and rDNA stability. In this review, we will focus on the nature of the molecular signatures that characterize a given epigenetic state of rDNA in mammalian cells, including noncoding RNA, DNA methylation and histone modifications, and the mechanisms by which they are established and maintained. This article is part of a Special Issue entitled: Transcription by Odd Pols. (C) 2012 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REMODELING COMPLEX NORC; RIBOSOMAL GENE-TRANSCRIPTION; FACTOR TTF-I; MOUSE RDNA SPACER; HETEROCHROMATIN FORMATION; DNA METHYLATION; NONCODING RNA; METHYLTRANSFERASE G9A; CHROMATIN STRUCTURES; NUCLEOLAR DOMINANCE; RNA polymerase I; Epigenetics; Nucleosome positioning; Histone modifications; DNA methylation; Noncoding RNA |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Gernot Längst |
| Depositing User: | Petra Gürster |
| Date Deposited: | 27 May 2020 10:49 |
| Last Modified: | 27 May 2020 10:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17047 |
Actions (login required)
 |
View Item |
