Sander, Paul Ramm and Hau, Peter and Koch, Steffen and Schuetze, Karin and Bogdahn, Ulrich and Kalbitzer, Hans Robert and Aigner, Ludwig (2013) Stem cell metabolic and spectroscopic profiling. TRENDS IN BIOTECHNOLOGY, 31 (3). pp. 204-213. ISSN 0167-7799, 1879-3096
Full text not available from this repository. (Request a copy)Abstract
Stem cells offer great potential for regenerative medicine because they regenerate damaged tissue by cell replacement and/or by stimulating endogenous repair mechanisms. Although stem cells are defined by their functional properties, such as the potential to proliferate, to self-renew, and to differentiate into specific cell types, their identification based on the expression of specific markers remains vague. Here, profiles of stem cell metabolism might highlight stem cell function more than the expression of single genes/markers. Thus, systematic approaches including spectroscopy might yield insight into stem cell function, identity, and sternness. We review the findings gained by means of metabolic and spectroscopic profiling methodologies, for example, nuclear magnetic resonance spectroscopy (NMRS), mass spectrometry (MS), and Raman spectroscopy (RS), with a focus on neural stem cells and neurogenesis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MAGNETIC-RESONANCE-SPECTROSCOPY; NEURAL PROGENITOR CELLS; VISIBLE LIPIDS; NEUROCHEMICAL PROFILE; GLUCOSE-OXIDATION; NMR-SPECTROSCOPY; GLIOMA-CELLS; FETAL-BRAIN; RAT-BRAIN; IN-VIVO; stem cells; metabolomics; NMR spectroscopy; mass spectrometry; Raman microspectroscopy; mobile lipids |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Medicine > Lehrstuhl für Neurologie Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer |
| Depositing User: | Petra Gürster |
| Date Deposited: | 02 Jun 2020 05:25 |
| Last Modified: | 02 Jun 2020 05:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17067 |
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