Rogenhofer, Sebastian and Miersch, Herdis and Goeke, Friederike and Kahl, Philip and Wieland, Wolf F. and Hofstaedter, Ferdinand and Kristiansen, Glen and von Ruecker, Alexander and Mueller, Stefan C. and Ellinger, Joerg (2013) Histone Methylation Defines an Epigenetic Entity in Penile Squamous Cell Carcinoma. JOURNAL OF UROLOGY, 189 (3). pp. 1117-1122. ISSN 0022-5347, 1527-3792
Full text not available from this repository. (Request a copy)Abstract
Purpose: Earlier studies indicate that epigenetics contribute to the pathogenesis of penile squamous cell carcinoma. Histone methylation patterns are frequently altered during carcinogenesis. Therefore, we investigated the methylation pattern of the histones H3K4, H3K9 and H3K27 in penile carcinoma and normal tissue. Materials and Methods: A tissue microarray was constructed with 65 penile carcinomas, 6 metastatic lesions and 30 control tissues. Global histone methylation was assessed using immunohistochemistry. Results: Global levels of H3K4me1, H3K9me1, H3K9me2, H3K27me2 and H3K27me3 were decreased, whereas H3K9me3 was increased in penile carcinoma. Histone methylation levels defined an epigenetic entity that allowed accurate differentiation of cancer and normal samples. We observed no correlation of histone methylation levels with clinicopathological parameters or patient outcome. Conclusions: The description of a definite epigenetic entity in penile carcinoma provides a rationale for testing epigenetic agents in patients with metastatic disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROGNOSTIC RELEVANCE; HUMAN-PAPILLOMAVIRUS; CANCER RECURRENCE; POOR-PROGNOSIS; BREAST-CANCER; DEMETHYLASE; INHIBITORS; SURVIVAL; RISK; GENE; penis; carcinoma, squamous cell; histones; methylation; epigenomics |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Apr 2020 05:37 |
| Last Modified: | 24 Apr 2020 05:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17095 |
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