Banerjee, Supratim and Koenig, Burkhard (2013) Molecular Imprinting of Luminescent Vesicles. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135 (8). pp. 2967-2970. ISSN 0002-7863,
Full text not available from this repository. (Request a copy)Abstract
Applying molecular imprinting techniques to the surface of functionalized unilammelar fluid vesicles allows the preparation of specific and high-affinity luminescent chemosensors. We have photopolymerized diacetylene containing vesicles in the presence of small peptides as templates yielding imprinted polydiacetylene (PDA) patches in the membrane. They serve as multivalent receptor sites with significantly increased rebinding affinity for the template. All binding sites are surface exposed and accessible for analyte binding. The presence of analytes is signaled with high sensitivity by emission intensity changes of amphiphilic carboxyfluorescein, which is coembedded into the fluid DOPC membrane. The merger of PDA imprinting with dynamic functionalized vesicles overcomes some of the current limitations of molecular imprinting in chemosensor design and may be applied to many different target analytes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BINDING-SITES; COLORIMETRIC DETECTION; ARTIFICIAL RECEPTORS; ENZYME-INHIBITORS; AQUEOUS-SOLUTION; CLICK CHEMISTRY; LIPID-MEMBRANES; RECOGNITION; SURFACE; CHEMOSENSORS; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Apr 2020 07:55 |
| Last Modified: | 24 Apr 2020 07:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17125 |
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