Raffler, Johannes and Roemisch-Margl, Werner and Petersen, Ann-Kristin and Pagel, Philipp and Bloechl, Florian and Hengstenberg, Christian and Illig, Thomas and Meisinger, Christa and Stark, Klaus and Wichmann, H-Erich and Adamski, Jerzy and Gieger, Christian and Kastenmueller, Gabi and Suhre, Karsten (2013) Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma. GENOME MEDICINE, 5: 13. ISSN 1756-994X,
Full text not available from this repository. (Request a copy)Abstract
Nuclear magnetic resonance spectroscopy (NMR) provides robust readouts of many metabolic parameters in one experiment. However, identification of clinically relevant markers in H-1 NMR spectra is a major challenge. Association of NMR-derived quantities with genetic variants can uncover biologically relevant metabolic traits. Using NMR data of plasma samples from 1,757 individuals from the KORA study together with 655,658 genetic variants, we show that ratios between NMR intensities at two chemical shift positions can provide informative and robust biomarkers. We report seven loci of genetic association with NMR-derived traits (APOA1, CETP, CPS1, GCKR, FADS1, LIPC, PYROXD2) and characterize these traits biochemically using mass spectrometry. These ratios may now be used in clinical studies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENOME-WIDE ASSOCIATION; HDL-CHOLESTEROL CONCENTRATIONS; FASTING GLUCOSE; ACID INTAKE; LOCI; TRIGLYCERIDE; METABOLOMICS; INTERACTS; VARIANTS; RISK; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Institut für Epidemiologie und Präventivmedizin Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Apr 2020 09:09 |
| Last Modified: | 24 Apr 2020 09:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17139 |
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