Berghoff, Anna Sophie and Spanberger, Thomas and Ilhan-Mutlu, Ayseguel and Magerle, Manuel and Hutterer, Markus and Woehrer, Adelheid and Hackl, Monika and Widhalm, Georg and Dieckmann, Karin and Marosi, Christine and Birner, Peter and Prayer, Daniela and Preusser, Matthias (2013) Preoperative Diffusion-Weighted Imaging of Single Brain Metastases Correlates with Patient Survival Times. PLOS ONE, 8 (2): e55464. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
Background: MRI-based diffusion-weighted imaging (DWI) visualizes the local differences in water diffusion in vivo. The prognostic value of DWI signal intensities on the source images and apparent diffusion coefficient (ADC) maps respectively has not yet been studied in brain metastases (BM). Methods: We included into this retrospective analysis all patients operated for single BM at our institution between 2002 and 2010, in whom presurgical DWI and BM tissue samples were available. We recorded relevant clinical data, assessed DWI signal intensity and apparent diffusion coefficient (ADC) values and performed histopathological analysis of BM tissues. Statistical analyses including uni- and multivariate survival analyses were performed. Results: 65 patients (34 female, 31 male) with a median overall survival time (OS) of 15 months (range 0-99 months) were available for this study. 19 (29.2%) patients presented with hyper-, 3 (4.6%) with iso-, and 43 (66.2%) with hypointense DWI. ADCmean values could be determined in 32 (49.2%) patients, ranged from 456.4 to 1691.8*10(-6) mm(2)/s (median 969.5) and showed a highly significant correlation with DWI signal intensity. DWI hyperintensity correlated significantly with high amount of interstitial reticulin deposition. In univariate analysis, patients with hyperintense DWI (5 months) and low ADCmean values (7 months) had significantly worse OS than patients with iso/hypointense DWI (16 months) and high ADCmean values (30 months), respectively. In multivariate survival analysis, high ADCmean values retained independent statistical significance. Conclusions: Preoperative DWI findings strongly and independently correlate with OS in patients operated for single BM and are related to interstitial fibrosis. Inclusion of DWI parameters into established risk stratification scores for BM patients should be considered.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BREAST-CANCER PATIENTS; TUMOR-STROMA RATIO; PROGNOSTIC VALUE; MRI; COEFFICIENT; CARCINOMA; CELLULARITY; DIAGNOSIS; PERFUSION; GLIOMAS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Apr 2020 07:08 |
| Last Modified: | 24 Apr 2020 07:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17160 |
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