Bellingrath, Silja and Rohleder, Nicolas and Kudielka, Brigitte M. (2013) Effort-reward-imbalance in healthy teachers is associated with higher LPS-stimulated production and lower glucocorticoid sensitivity of interleukin-6 in vitro. BIOLOGICAL PSYCHOLOGY, 92 (2). pp. 403-409. ISSN 0301-0511, 1873-6246
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Background: According to the effort-reward-imbalance (ER!) model, a lack of reciprocity between costs and gains at work increases the risk for adverse health outcomes. Inflammation has been shown to play a crucial role in a variety of stress-related diseases and alterations in immune system glucocorticoid sensitivity may help to explain the increased risk for cardiovascular disease (CVD) and depression related to chronic work stress. Methods: Changes in lipopolysaccharide (LPS)-induced interleukin (IL)-6 production and inhibition of IL-6 production by dexamethasone in reaction to the Trier Social Stress Test (TSST) were assessed in forty-six healthy school teachers to test whether chronic work stress is accompanied by alterations in inflammatory activity and glucocorticoid sensitivity of the innate immune system. Results: High ERI was associated with an increase in pro-inflammatory potential, reflected in elevated IL-6 production before and after stress and with a lower capacity of dexamethasone to suppress IL-6 production in vitro over all measurement time points. ERI was not associated with stress-related changes in GC sensitivity. Conclusion: The present findings suggest a less effective anti-inflammatory regulation by glucocorticoids in teachers suffering from chronic work stress. (C) 2012 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORONARY-HEART-DISEASE; INFLAMMATORY CYTOKINE PRODUCTION; ACUTE PSYCHOSOCIAL STRESS; RECEPTOR-BETA-ISOFORM; JOB STRESS; MYOCARDIAL-INFARCTION; PSYCHOLOGICAL STRESS; SCHOOL TEACHERS; CHINESE WORKERS; CARDIOVASCULAR-DISEASE; Effort-reward-imbalance; Pro-inflammatory cytokine production; Glucocorticoid sensitivity; Trier Social Stress Test (TSST); Chronic work stress |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie VII (Medizinische Psychologie, Psychologische Diagnostik und Methodenlehre) - Prof. Dr. Brigitte Kudielka |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Apr 2020 12:18 |
| Last Modified: | 24 Apr 2020 12:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17192 |
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