Zygmanski, Piotr and Hoegele, Wolfgang and Tsiamas, Panagiotis and Cifter, Fulya and Ngwa, Wil and Berbeco, Ross and Makrigiorgos, Mike and Sajo, Erno (2013) A stochastic model of cell survival for high-Z nanoparticle radiotherapy. MEDICAL PHYSICS, 40 (2): 024102. ISSN 0094-2405,
Full text not available from this repository. (Request a copy)Abstract
Purpose: The authors present a stochastic framework for the assessment of cell survival in gold nanoparticle radiotherapy. Methods: The authors derive the equations for the effective macroscopic dose enhancement for a population of cells with nonideal distribution of gold nanoparticles (GNP), allowing different number of GNP per cell and different distances with respect to the cellular target. They use the mixed Poisson distribution formalism to model the impact of the aforementioned physical factors on the effective dose enhancement. Results: The authors show relatively large differences in the estimation of cell survival arising from using approximated formulae. They predict degeneration of the cell killing capacity due to different number of GNP per cell and different distances with respect to the cellular target. Conclusions: The presented stochastic framework can be used in interpretation of experimental cell survival or tumor control probability studies. c 2013 American Association of Physicists in Medicine. [http://dx.doi.org/10.1118/1.4773885]
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LOCAL EFFECT MODEL; MONTE-CARLO-SIMULATION; GOLD NANOPARTICLES; DOSE ENHANCEMENT; RADIATION-THERAPY; CLINICAL SCENARIO; MAMMALIAN-CELLS; PHOTON ENERGY; X-RAY; DNA; gold; nanoparticle; LEM; RBE |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Strahlentherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Apr 2020 09:06 |
| Last Modified: | 28 Apr 2020 09:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17207 |
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