Steppan, Dominik and Zuegner, Anita and Rachel, Reinhard and Kurtz, Armin (2013) Structural analysis suggests that renin is released by compound exocytosis. KIDNEY INTERNATIONAL, 83 (2). pp. 233-241. ISSN 0085-2538, 1523-1755
Full text not available from this repository. (Request a copy)Abstract
The mode of renin release from renal juxtaglomerular cells into circulation is still unsolved in several aspects. Here we studied the intracellular organization of renin-storage vesicles and their changes during controlled stimulation of renin release. This was accomplished using isolated perfused mouse kidneys with 3-dimensional electron microscopic analyses of renin-producing cells. Renin was found to be stored in a network of single granules and cavern-like structures, and dependent on the synthesis of glycosylated prorenin. Acute stimulation of renin release led to increased exocytosis in combination with intracellular fusion of vesicles to larger caverns and their subsequent emptying. Renin release from the kidneys of SCID-beige mice, which contain few but gigantic renin-storage vesicles, was no different from that of kidneys from wild-type mice. Thus, our findings suggest that renin is released by mechanisms similar to compound exocytosis. Kidney International (2013) 83, 233-241; doi:10.1038/ki.2012.392; published online 12 December 2012
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | JUXTAGLOMERULAR EPITHELIOID CELLS; PANCREATIC BETA-CELLS; SECRETORY GRANULES; AFFERENT ARTERIOLES; CUMULATIVE FUSION; CONVERTING ENZYME; MOLECULAR-BIOLOGY; MEMBRANE-FUSION; MOUSE KIDNEY; EOSINOPHILS; afferent arteriole; angiotensin; renin-angiotensin system |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz Biology, Preclinical Medicine > Institut für Anatomie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Apr 2020 06:35 |
| Last Modified: | 27 Apr 2020 06:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17227 |
Actions (login required)
 |
View Item |
