Reinhold, Stephan W. and Scherl, Thomas and Stoelcker, Benjamin and Bergler, Tobias and Hoffmann, Ute and Weingart, Christian and Banas, Miriam C. and Kollins, Dmitrij and Kammerl, Martin C. and Krueger, Bernd and Kaess, Bernhard and Kraemer, Bernhard K. and Banas, Bernhard (2013) Lipoxygenase Products in the Urine Correlate with Renal Function and Body Temperature but not with Acute Transplant Rejection. LIPIDS, 48 (2). pp. 167-175. ISSN 0024-4201, 1558-9307
Full text not available from this repository. (Request a copy)Abstract
Acute transplant rejection is the leading cause of graft loss in the first months after kidney transplantation. Lipoxygenase products mediate pro- and anti-inflammatory actions and thus we aimed to correlate the histological reports of renal transplant biopsies with urinary lipoxygenase products concentrations to evaluate their role as a diagnostic marker. This study included a total of 34 kidney transplant recipients: 17 with an acute transplant rejection and 17 controls. LTE4, LTB4, 12-HETE and 15-HETE concentrations were measured by enzyme immunoassay. Urinary lipoxygenase product concentrations were not significantly changed during an acute allograft rejection. Nevertheless, LTB4 concentrations correlated significantly with the body temperature (P a parts per thousand currency sign 0.05) 3 months after transplantation, and 12- and 15-HETE concentrations correlated significantly with renal function (P a parts per thousand currency sign 0.05) 2 weeks after transplantation. In conclusion, our data show a correlation for LTB4 with the body temperature 3 months after transplantation and urinary 12- and 15-HETE concentrations correlate positively with elevated serum creatinine concentrations but do not predict acute allograft rejection.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ISCHEMIA-REPERFUSION INJURY; ARACHIDONIC-ACID METABOLISM; ALLOGRAFT-REJECTION; T-CELLS; ULCERATIVE-COLITIS; GENE-EXPRESSION; LEUKOTRIENE B-4; HUMAN-MONOCYTES; FISH-OIL; INHIBITION; Lipoxygenase product; Leukotriene E4; Leukotriene B4; 12-HETE; 15-HETE; Biomarker |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Apr 2020 07:17 |
| Last Modified: | 27 Apr 2020 07:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17233 |
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