Schlaier, Juergen Ralf and Habermeyer, Christine and Janzen, Annette and Fellner, Claudia and Hochreiter, Andreas and Proescholdt, Martin and Brawanski, Alexander and Lange, Max (2013) The influence of intraoperative microelectrode recordings and clinical testing on the location of final stimulation sites in deep brain stimulation for Parkinson's disease. ACTA NEUROCHIRURGICA, 155 (2). pp. 357-366. ISSN 0001-6268, 0942-0940
Full text not available from this repository. (Request a copy)Abstract
The goal of our study was to investigate the influence of intraoperative microelectrode recordings and clinical testing on the location of the final stimulation site in deep brain stimulation in Parkinson's disease. In 22 patients with Parkinson's disease we compared magnetic resonance imaging (MRI)-based and atlas-based targets with the adjusted stimulation sites after intraoperative, multitrack microelectrode recording (MER) and intraoperative and postoperative clinical testing. The investigation included 176 target/stimulation sites in 44 subthalamic nuclei (STNs), which were related to a standardised three-dimensional, MRI-defined STN. Atlas-based targets were positioned more superior and more medial than the MRI-based targets, which were located in the centre of the MRI-STN. The optimal stimulation sites, found intraoperatively after MER and clinical testing, were located more lateral and slightly more superior than both planned targets. In the majority of the cases the location of the active contact was the most superior and most lateral of all target sites. The differences in the distributions of those four targets reached statistical significance. However, final active contacts were distributed throughout the MRI-defined STN and its immediate surroundings. The adoption of microelectrode recordings and extensive clinical testing allows the adjustment of anatomical targeting even to unexpected stimulation sites in and around the MRI-defined STN.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SUBTHALAMIC NUCLEUS; BASAL GANGLIA; MRI; IMPLANTATION; HEMORRHAGE; ANATOMY; SURGERY; RISK; Deep brain stimulation; Subthalamic nucleus; Microelectrode recording; Parkinson's disease; Targeting |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie Medicine > Lehrstuhl für Neurologie Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Apr 2020 07:19 |
| Last Modified: | 27 Apr 2020 07:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17235 |
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