Macabeo, Allan Patrick G. and Letada, Arianne G. and Budde, Simon and Faderl, Christian and Dahse, Hans-Martin and Franzblau, Scott G. and Alejandro, Grecebio Jonathan D. and Pierens, Gregory K. and Garso, Mary J. (2017) Antitubercular and Cytotoxic Chlorinated seco-Cyclohexenes from Uvaria alba. JOURNAL OF NATURAL PRODUCTS, 80 (12). pp. 3320-3324. ISSN 0163-3864, 1520-6025
Full text not available from this repository. (Request a copy)Abstract
Two new chlorine-containing polyoxygenated seco-cyclohexenes, albanols A (1) and B (2), along with the oxepinone metabolite grandiuvarone (3) were isolated from the endemic Philippine Annonaceae plant Uvaria alba. Both new compounds exhibited modest antitubercular activity. Compound 1 showed cytostatic activity (ranging from 1-50 mu M) against HeLa cells and weak antiproliferative activity against HUVEC and K-562 cells with GI50 values of 106 and 81 mu M, respectively.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MYCOBACTERIUM-TUBERCULOSIS; CONSTITUENTS; ANNONACEAE; VALDERRAMENSIS; DERIVATIVES; RUFA; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:18 |
| Last Modified: | 20 Feb 2019 08:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1729 |
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