Kirschneck, Christian and Proff, Peter and Fanghaenel, Jochen and Behr, Michael and Wahlmann, Ulrich and Roemer, Piero (2013) Differentiated analysis of orthodontic tooth movement in rats with an improved rat model and three-dimensional imaging. ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER, 195 (6). pp. 539-553. ISSN 0940-9602, 1618-0402
Full text not available from this repository. (Request a copy)Abstract
Rat models currently available for analysis of orthodontic tooth movement often lack differentiated, reliable and precise measurement systems allowing researchers to separately investigate-the individual contribution of tooth tipping, body translation and root torque to overall displacement. Many previously proposed models have serious limitations such as the rather inaccurate analysis of the effects of orthodontic forces on rat incisors. We therefore developed a differentiated measurement system that was used within a rat model with the aim of overcoming the limitations of previous studies. The first left upper molar and the upper incisors of 24 male Wistar rats were subjected to a constant orthodontic force of 0.25 N by means of a NiTi closed coil spring for up to four weeks. The extent of the various types of tooth movement was measured optometrically with a CCD microscope camera and cephalometrically by means of cone beam computed tomography (CBCT). Both types of measurement proved to be reliable for consecutive measurements and the significant tooth movement induced had no harmful effects on the animals. Movement kinetics corresponded to known physiological processes and tipping and body movement equally contributed to the tooth displacement. The upper incisors of the rats were significantly deformed and their natural eruption was effectively halted. The results showed that our proposed measurement systems used within a rat model resolved most of the inadequacies of previous studies. They are reliable, precise and physiological tools for the differentiated analysis of orthodontic tooth movement while simultaneously preserving animal welfare. (C) 2013 Elsevier GmbH. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ROOT RESORPTION; ALVEOLAR BONE; FORCE; MOLARS; LIGHT; ATTACHMENT; TISSUE; MICE; ZOLEDRONATE; OSTEOCLAST; Wistar rats; Tooth movement; Orthodontics; Orthodontic model; Cone beam computed tomography; Cephalometry; Animal models |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kieferorthopädie Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie Medicine > Lehrstuhl für Zahnärztliche Prothetik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Apr 2020 09:53 |
| Last Modified: | 28 Apr 2020 09:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17331 |
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