Aziz, A. and Gierth, M. and Fritsche, H. M. and May, M. and Otto, W. and Denzinger, S. and Wieland, W. F. and Merseburger, A. and Riedmiller, H. and Kocot, A. and Burger, M. (2013) Oncological Outcome of Primary versus Secondary Muscle-Invasive Bladder Cancer Is Comparable after Radical Cystectomy. UROLOGIA INTERNATIONALIS, 91 (1). pp. 97-102. ISSN 0042-1138, 1423-0399
Full text not available from this repository. (Request a copy)Abstract
Background: High-risk non-muscle-invasive bladder cancer (NMIBC) progressing to muscle-invasive bladder cancer (MIBC) is associated with adverse tumour biology. It is unclear, however, whether outcome of NMIBC progressing to MIBC is adverse compared to primary MIBC and whether NMIBC of higher risk of progression to MIBC is adverse compared to NMIBC of lower risk. Objective: Our objective was to assess cancer-specific survival (CSS) following radical cystectomy (RC) for primary MIBC and for NMIBC progressing to MIBC in dependence of EORTC risk score. Materials and Methods: Clinical and histopathological characteristics and CSS of 150 patients were assessed. Secondary MIBCs were stratified by EORTC risk score at the last transurethral resection of bladder tumour for NMIBC. Results: CSS did not differ significantly between primary and secondary MIBC (p = 0.521). Secondary MIBC with high EORTC score had significantly shorter CSS compared to secondary MIBC with intermediate EORTC score (p = 0.029). In multivariable analysis, pathological tumour stage (HR = 3.77; p = 0.020) and lymph node stage (HR = 2.34; p = 0.022) were significantly correlated with CSS. Conclusion: While the outcome of secondary MIBC is not generally adverse compared to primary MIBC, the EORTC risk score not only reflects high risk of progression of NMIBC to MIBC, but also worse outcome following RC for secondary MIBC. Timely RC should thus be debated in high-risk NMIBC. Copyright (C) 2013 S. Karger AG, Basel
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EORTC RISK TABLES; UROTHELIAL CARCINOMA; MOLECULAR MARKERS; SURVIVAL; STAGE; DELAY; PROGRESSION; RECURRENCE; DIAGNOSIS; TUMOR; Bladder cancer; Risk stratification; EORTC risk tables; Prognosis; Progression; Radical cystectomy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Apr 2020 13:20 |
| Last Modified: | 28 Apr 2020 13:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17383 |
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