Dulla, Balakrishna and Kirla, Krishna Tulasi and Rathore, Vandana and Deora, Girdhar Singh and Kavela, Sridhar and Maddika, Subbareddy and Chatti, Kiranam and Reiser, Oliver and Iqbal, Javed and Pal, Manojit (2013) Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties. ORGANIC & BIOMOLECULAR CHEMISTRY, 11 (19). pp. 3103-3107. ISSN 1477-0520,
Full text not available from this repository. (Request a copy)Abstract
A series of functionalized phenyl oxazole derivatives was designed, synthesized and screened in vitro for their activities against LSD1 and for effects on viability of cervical and breast cancer cells, and in vivo for effects using zebrafish embryos. These compounds are likely to act via multiple epigenetic mechanisms specific to cancer cells including LSD1 inhibition.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HISTONE DEMETHYLASE LSD1; ANALOGS; RECEPTOR; REEXPRESSION; INACTIVATOR; CHROMATIN; GENES; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Apr 2020 06:10 |
| Last Modified: | 29 Apr 2020 06:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17440 |
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