Wiggermann, P. and Wohlgemuth, W. A. and Heibl, M. and Vasilj, A. and Loss, M. and Schreyer, A. G. and Stroszczynski, C. and Jung, E. M. (2013) Dynamic evaluation and quantification of microvascularization during degradable starch microspheres transarterial Chemoembolisation (DSM-TACE) of HCC lesions using contrast enhanced ultrasound (CEUS): A feasibility study. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 53 (4). pp. 337-348. ISSN 1386-0291, 1875-8622
Full text not available from this repository. (Request a copy)Abstract
PURPOSE: To evaluate the time dependent changes of microcirculation in hepatocellular carcinoma (HCC) lesions during degradable starch microsphere (DSM)-TACE using contrast enhanced ultrasound (CEUS). MATERIALS AND METHODS: A total of 48 CEUS examinations were performed (1-5 MHz, convex probe) in 6 selected patients who underwent DSM-TACE with EmboCept (R) S for the treatment of HCC lesions. I.v. application of ultrasound contrast media was performed before and 24 hours post embolization. In addition i.a. contrast application was performed via the angiographic catheter right before and after the embolization and during a follow up time of 2 hours every 30 minutes. The capillary circulation of the treated HCC lesions was analyzed and quantitative perfusion analysis was performed using a perfusion software by two experienced radiologists in consensus. RESULTS: A significantly reduced microvascularization was seen right after DSM-TACE in all cases using CEUS. The reduction of PEAK, RBV (regional blood volume) and RBF (regional blood flow) compared to preembolization values was highly significant. Mean PEAK was 34.3 +/- 13.1 prior to embolization and 9.4 +/- 9.1 post embolization (p < 0.001). Mean RBV was 446.5 +/- 122.4 prior to embolization and 70.9 +/- 23.8 post embolization (p < 0.001). The corresponding figures for RBF were 34.7 +/- 13.4 prior- and 4.8 +/- 3.4 post embolization (p < 0.001). During follow up a stepwise revascularization of the lesions was documented: 90 minutes post embolization perfusion parameters were not significantly different from prae-embolization values. CONCLUSION: In this feasibility study, capillary perfusion quantification of HCC lesions after DSM-TACE could be demonstrated using CEUS. Using quantitative perfusion analysis it was possible to quantify the transient embolizing effect of DSM-TACE.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | UNRESECTABLE HEPATOCELLULAR-CARCINOMA; BOWEL WALL VASCULARIZATION; QUANTITATIVE ASSESSMENT; STRESS ECHOCARDIOGRAPHY; ARTERIAL EMBOLIZATION; MYOCARDIAL-ISCHEMIA; CROHNS-DISEASE; BLOOD-FLOW; PERFUSION; TIME; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Apr 2020 06:53 |
| Last Modified: | 29 Apr 2020 06:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17443 |
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