Behrens, Gundula and Matthews, Charles E. and Moore, Steven C. and Freedman, Neal D. and McGlynn, Katherine A. and Everhart, James E. and Hollenbeck, Albert R. and Leitzmann, Michael F. (2013) The association between frequency of vigorous physical activity and hepatobiliary cancers in the NIH-AARP Diet and Health Study. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 28 (1). pp. 55-66. ISSN 0393-2990, 1573-7284
Full text not available from this repository. (Request a copy)Abstract
Despite a potential preventive effect of physical activity on hepatobiliary cancer, little information is available on the relation between the two. We studied the association between frequency of vigorous physical activity and hepatobiliary cancer among 507,897 participants of the NIH-AARP Diet and Health Study, aged 50-71 years at baseline in 1995/1996. During 10 years of follow-up, 628 incident cases of liver cancer and 317 cases of extrahepatic biliary tract cancer were registered. Physical activity levels were assigned according to the frequency of engagement in 20 min or more of vigorous physical activity per week: never/rarely (lowest level), less than once per week, 1-2 times per week, 3-4 times per week, 5 or more times per week (highest level). Using Cox regression, multivariate-adjusted relative risks (RR) comparing the highest with the lowest level of physical activity revealed a statistically significant decreased risk for liver cancer (RR = 0.64, 95 % confidence interval (CI) = 0.49-0.84, p-trend < 0.001), particularly hepatocellular carcinoma (RR = 0.56, 95 % CI = 0.41-0.78, p-trend < 0.001), independent of body mass index. By comparison, multivariate analyses indicated that physical activity was not statistically significantly associated with extrahepatic bile duct cancer (RR = 0.86, 95 % CI = 0.45-1.65), ampulla of Vater cancer (RR = 0.66, 95 % CI = 0.29-1.48), or gallbladder cancer (RR = 0.63, 95 % CI = 0.33-1.21). These results suggest a potential preventive effect of physical activity on liver cancer but not extrahepatic biliary tract cancer, independent of body mass index.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEPATOCELLULAR-CARCINOMA; LIVER-CANCER; REPRODUCTIVE FACTORS; OXIDATIVE STRESS; PROSPECTIVE COHORT; OBESE INDIVIDUALS; RISK; EXERCISE; ANTIOXIDANT; INCREASES; Physical activity; Liver cancer; Biliary cancer; Gallbladder cancer; Cohort study |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Apr 2020 06:58 |
| Last Modified: | 29 Apr 2020 06:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17461 |
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