Gunia, Sven and Burger, Maximilian and Hakenberg, Oliver W. and May, Dieter and Koch, Stefan and Jain, Anjun and Birnkammer, Kristina and Wieland, Wolf F. and Otto, Wolfgang and Hofstaedter, Ferdinand and Fritsche, Hans-Martin and Denzinger, Stefan and Gilfrich, Christian and Brookman-May, Sabine and May, Matthias (2013) Inherent Grading Characteristics of Individual Pathologists Contribute to Clinically and Prognostically Relevant Interobserver Discordance Concerning Broders' Grading of Penile Squamous Cell Carcinomas. UROLOGIA INTERNATIONALIS, 90 (2). pp. 207-213. ISSN 0042-1138, 1423-0399
Full text not available from this repository. (Request a copy)Abstract
Introduction: We assessed the reproducibility and prognostic impact of the Broders' grading system (BGS) in a cohort of 147 patients with surgically treated penile squamous cell carcinomas. Materials and Methods:Conventionally stained histology slides were graded according to the BGS in two rounds by two study pathologists. Reproducibility was assessed using K statistics. Multivariable analyses were calculated to predict cancer-specific survival (CSS). The 'mean grade' per pathologist per round was calculated by allocating grade points to each study case (G1-G4: 1-4 points) and dividing the sum of all grade points by the number of cases examined. Results: The BGS showed substantial interobserver variation (59-87% with kappa = 0.38-0.69) but almost perfect intraobserver reproducibility (91% with kappa = 0.86 and 96% with kappa = 0.94, respectively). The 'mean grade' per pathologist remained nearly constant in both rounds of examination (differences <= 0.05 grade points) but differed between the two pathologists (up to 0.4 grade points). In multivariable analyses, the prognostic impact of the BGS in terms of CSS was strongly pathologist-dependent. Conclusions: Clinically and prognostically relevant interobserver discordance concerning the BGS seems, at least in part, to be attributable to inherent 'aggressive' versus 'reserved' grading characteristics of individual pathologists. Copyright (C) 2012 S. Karger AG, Basel
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HISTOLOGIC GRADE; SPECIMENS; P16(INK4A); PROGNOSIS; BIOPSY; MARKER; Penile squamous cell carcinoma; Broders' grading system; Interobserver reproducibility; Prognostic evaluation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Apr 2020 07:12 |
| Last Modified: | 29 Apr 2020 07:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17467 |
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