Herzberg, P. Y. and Lee, S. J. and Heussner, P. and Mumm, F. H. A. and Hilgendorf, I. and von Harsdorf, S. and Hemmati, P. and Rieger, K. and Greinix, H. T. and Freund, M. and Holler, E. and Wolff, D. (2013) Personality influences quality-of-life assessments in adult patients after allogeneic hematopoietic SCT: results from a joint evaluation of the prospective German Multicenter Validation Trial and the Fred Hutchinson Cancer Research Center. BONE MARROW TRANSPLANTATION, 48 (1). pp. 129-134. ISSN 0268-3369,
Full text not available from this repository. (Request a copy)Abstract
The influence of personality on health related quality of life (QoL) and physical functioning in the setting of allogeneic hematopoietic SCT (alloHSCT) is unknown. We conducted a joint evaluation within two independent cohorts of alloHSCT recipients to investigate the impact of personality on reported QoL and physical functioning. Two-hundred-eight patients (median age 44 years, range 18-72) of cohort 1 and 93 patients (median age 55 years, range 19-79) of cohort 2 after alloHSCT were evaluated. Personality was assessed using the 24-adjective measure (AM), which measures the Big-Five personality domains and the Life Orientation Test-Revised (LOT-R), measuring optimism and pessimism. QoL was measured using the Functional Assessment of Cancer Therapy with bone marrow transplantation subscale (FACT-BMT), Short Form 36 (SF-36), the human activity profile (HAP), as well as the NIH criteria-based cGVHD activity assessment form and the Lee cGVHD symptom scale. Neuroticism was significantly associated with worse function measured by the HAP and FACT-BMT. Optimism significantly improved QoL captured by the FACT-BMT. Pessimism significantly impaired physical function captured by the HAP and SF-36. Extraversion was significantly associated with reduced depression and lower severity of cGVHD symptoms reported by the patient and the physician. The results suggest that personality traits and pre-treatment QoL assessments should be measured in clinical trials to facilitate the interpretation of QoL data. Bone Marrow Transplantation (2013) 48, 129-134; doi:10.1038/bmt.2012.83; published online 21 May 2012
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; CONSENSUS DEVELOPMENT PROJECT; WORKING GROUP-REPORT; STAGE BREAST-CANCER; PSYCHOLOGICAL DISTRESS; CELL TRANSPLANTATION; OPTIMISM-PESSIMISM; ORIENTATION TEST; CLINICAL-TRIALS; HEALTH-STATUS; allogeneic hematopoietic SCT; personality; GVHD; quality of life; physical functioning |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Apr 2020 08:54 |
| Last Modified: | 29 Apr 2020 08:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17505 |
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