Ediebah, D. E. and Coens, C. and Maringwa, J. T. and Quinten, C. and Zikos, E. and Ringash, J. and King, M. and Gotay, C. and Flechtner, H. -H. and von Koch, J. Schmucker and Weis, J. and Smit, E. F. and Koehne, C. -H. and Bottomley, A. (2013) Effect of completion-time windows in the analysis of health-related quality of life outcomes in cancer patients. ANNALS OF ONCOLOGY, 24 (1). pp. 231-237. ISSN 0923-7534,
Full text not available from this repository. (Request a copy)Abstract
We examined if cancer patients' health-related quality of life (HRQoL) scores on the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 are affected by the specific time point, before or during treatment, at which the questionnaire is completed, and whether this could bias the overall treatment comparison analyses. A 'completion-time window' variable was created on three closed EORTC randomised control trials in lung (non-small cell lung cancer, NSCLC) and colorectal cancer (CRC) to indicate when the QLQ-30 was completed relative to chemotherapy cycle dates, defined as 'before', 'on' and 'after'. HRQoL mean scores were calculated using a linear mixed model. Statistically significant differences (P < 0.05) were observed on 6 and 5 scales for 'on' and 'after' comparisons in the NSCLC and two-group CRC trial, respectively. As for the three-group CRC trial, several statistical differences were observed in the 'before' to 'on' and the 'on' to 'after' comparisons. For all three trials, including the 'completion-time window' variable in the model resulted in a better fit, but no substantial changes in the treatment effects were noted. We showed that considering the exact timing of completion within specified windows resulted in statistical and potentially clinically significant differences, but it did not alter the conclusions of treatment comparison in these studies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADVANCED BREAST-CANCER; CELL LUNG-CANCER; PHASE-III TRIAL; EUROPEAN-ORGANIZATION; COLORECTAL-CANCER; EORTC QLQ-C30; CLINICAL-TRIALS; QUESTIONNAIRE; CHEMOTHERAPY; RESPONSIVENESS; cancer clinical trial; completion-time window; health-related quality of life; quality of life |
| Subjects: | 100 Philosophy & psychology > 100 Philosophy |
| Divisions: | Philosophy, Art History, History, and Humanities > Institut für Philosophie > Alumni or Retired Professors > Prof. Dr. phil. habil. Joseph F. Schmucker-von Koch |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Apr 2020 12:02 |
| Last Modified: | 30 Apr 2020 12:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17517 |
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