Aleksandrova, Krasimira and Jenab, Mazda and Leitzmann, Michael and Bueno-de-Mesquita, Bas and Kaaks, Rudolf and Trichopoulou, Antonia and Bamia, Christina and Lagiou, Pagona and Rinaldi, Sabina and Freisling, Heinz and Carayol, Marion and Pischon, Tobias and Drogan, Dagmar and Weiderpass, Elisabete and Jakszyn, Paula and Overvad, Kim and Dahm, Christina C. and Tjonneland, Anne and Bouton-Ruault, Marie-Christine and Kuehn, Tilman and Peppa, Eleni and Valanou, Elissavet and La Vecchia, Carlo and Palli, Domenico and Panico, Salvatore and Sacerdote, Carlotta and Agnoli, Claudia and Tumino, Rosario and May, Anne and van Vulpen, Jonna and Borch, Kristin Benjaminsen and Oyeyemi, Sunday Oluwafemi and Ramon Quiros, J. and Bonet, Catalina and Sanchez, Maria-Jose and Dorronsoro, Miren and Navarro, Carmen and Barricarte, Aurelio and van Guelpen, Bethany and Wennberg, Patrik and Key, Timothy J. and Khaw, Kay-Tee and Wareham, Nicholas and Assi, Nada and Ward, Heather A. and Aune, Dagfinn and Riboli, Elio and Boeing, Heiner (2017) Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 46 (6). pp. 1823-1835. ISSN 0300-5771, 1464-3685
Full text not available from this repository. (Request a copy)Abstract
There is convincing evidence that high physical activity lowers the risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We aimed to determine the extent to which body fatness and biomarkers of various biologically plausible pathways account for the association between physical activity and colon cancer. We conducted a nested case-control study in a cohort of 519 978 men and women aged 25 to 70 years followed from 1992 to 2003. A total of 713 incident colon cancer cases were matched, using risk-set sampling, to 713 controls on age, sex, study centre, fasting status and hormonal therapy use. The amount of total physical activity during the past year was expressed in metabolic equivalent of task [MET]-h/week. Anthropometric measurements and blood samples were collected at study baseline. High physical activity was associated with a lower risk of colon cancer: relative risk >= 91 MET-h/week vs < 91 MET-h/week = 0.75 [95% confidence interval (CI): 0.57 to 0.96]. In mediation analyses, this association was accounted for by waist circumference: proportion explained effect (PEE) = 17%; CI: 4% to 52%; and the biomarkers soluble leptin receptor (sOB-R): PEE = 15%; 95% CI: 1% to 50% and 5-hydroxyvitamin D (25[OH]D): PEE = 30%; 95% CI: 12% to 88%. In combination, these factors explained 45% (95% CI: 20% to 125%) of the association. Beyond waist circumference, sOB-R and 25[OH]D additionally explained 10% (95% CI: 1%; 56%) and 23% (95% CI: 6%; 111%) of the association, respectively. Promoting physical activity, particularly outdoors, and maintaining metabolic health and adequate vitamin D levels could represent a promising strategy for colon cancer prevention.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SOLUBLE LEPTIN RECEPTOR; COLORECTAL-CANCER; VITAMIN-D; METABOLIC SYNDROME; NUTRITION COHORT; CONTROLLED-TRIAL; RECTAL CANCERS; SERUM-LEVELS; WEIGHT-LOSS; METAANALYSIS; Physical activity; colon cancer; mediating factors; adiposity; biomarkers |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:19 |
| Last Modified: | 20 Feb 2019 15:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1754 |
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