Wolfram, Maren and Bellingrath, Silja and Feuerhahn, Nicolas and Kudielka, Brigitte M. (2013) Emotional exhaustion and overcommitment to work are differentially associated with hypothalamus-pituitary-adrenal (HPA) axis responses to a low-dose ACTH(1-24) (Synacthen) and dexamethasone-CRH test in healthy school teachers. STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, 16 (1). pp. 54-64. ISSN 1025-3890, 1607-8888
Full text not available from this repository. (Request a copy)Abstract
Evidence for a detrimental impact of chronic work stress on health has accumulated in epidemiological research. Recent studies indicate altered hypothalamus-pituitary-adrenal (HPA) axis regulation as a possible biological pathway underlying the link between stress and disease. However, the direction of dysregulation remains unclear, with reported HPA hyper- or hyporeactivity. To disentangle potential effects on different functional levels in the HPA axis, we examined responses using two pharmacological stimulation tests in 53 healthy teachers (31 females, 22 males; mean age: 49.3 years; age range: 30-64 years): a low-dose adrenocorticotrophic hormone (ACTH(1-24), Synacthen) test was used to assess adrenal cortex sensitivity and the combined dexamethasone-corticotropin releasing hormone (DEX-CRH) test to examine pituitary and adrenal cortex reactivity. Blood and saliva samples were collected at 21, + 15, + 30, + 45, + 60, + 90, + 120 min. Emotional exhaustion (EE), the core dimension of burnout, was measured with the Maslach Burnout Inventory. Overcommitment (OC) was assessed according to Siegrist's effort-reward-imbalance model. We found a significant association between EE and higher plasma cortisol profiles after Synacthen (p = 0.045). By contrast, OC was significantly associated with attenuated ACTH (p = 0.045), plasma cortisol (p = 0.005), and salivary cortisol (p = 0.023) concentrations following DEX-CRH. Results support the notion of altered HPA axis regulation in chronically work-stressed teachers, with differential patterns of hyper- and hyporeactivity depending on individual stress condition and the tested functional level of the HPA axis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACUTE PSYCHOSOCIAL STRESS; EFFORT-REWARD-IMBALANCE; CORTISOL AWAKENING RESPONSE; JOB-STRESS; CLINICAL BURNOUT; DEPRESSION SCALE; HOSPITAL ANXIETY; WHITEHALL II; DISORDERS; EMPLOYMENT; ACTH(1-24) (Synacthen) test; chronic work stress; dexamethasone-CRH test; emotional exhaustion; HPA axis regulation; overcommitment |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Human Sciences > Institut für Psychologie Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie VII (Medizinische Psychologie, Psychologische Diagnostik und Methodenlehre) - Prof. Dr. Brigitte Kudielka |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Apr 2020 05:21 |
| Last Modified: | 30 Apr 2020 05:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/17554 |
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