Markus, M. R. P. and Ittermann, T. and Wittfeld, K. and Schipf, S. and Siewert-Markus, U. and Bahls, M. and Buelow, R. and Werner, N. and Janowitz, D. and Baumeister, S. E. and Felix, S. B. and Doerr, M. and Rathmann, W. and Voelzke, H. and Grabe, H. J. (2017) Prediabetes is associated with lower brain gray matter volume in the general population. The Study of Health in Pomerania (SHIP). NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 27 (12). pp. 1114-1122. ISSN 0939-4753, 1590-3729
Full text not available from this repository. (Request a copy)Abstract
Background and aims: We investigated the associations of fasting (FG) and 2h postload (2HG) plasma glucose from oral glucose tolerance test (OGTT) with gray (GMV) and white (WMV) matter volume. Methods and results: We analyzed data from 1330 subjects without known diabetes mellitus, aged 21 to 81, from the second cohort (SHIP-Trend-0) of the population-based Study of Health in Pomerania (SHIP). Following the OGTT, individuals were classified in five groups (according to the American Diabetes Association criteria): normal glucose tolerance (NGT), isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), combined IFG and IGT (IFG + IGT) and unknown type 2 diabetes mellitus (UDM). GMV and WMV were determined by magnetic resonance imaging. FG, 2HG and OGTT groups were associated with GMV and WMV by linear regression models adjusted for confounders. FG and 2HG were inversely associated with GMV. The adjusted mean GMV, when compared with the NGT group (584 ml [95% CI: 581 to 587]), was significantly lower in the groups i-IFG (578 ml [95% CI: 573 to 582]; p=0.035) and UDM (562 ml [95% CI: 551 to 573]; p < 0.001), but not different in the i-IGT (586 ml [95% CI: 576 to 596]; p=0.688) and IFG + IGT (579ml [95% CI: 571 to 586]; p=0.209) groups. There were no associations of FG, 2HG and OGTT parameters with WMV. Conclusion: Our findings suggest that elevated FG levels, even within the prediabetic range, might already have some harmful effects on GMV. (c) 2017 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HIPPOCAMPAL ATROPHY; CORTICAL THICKNESS; ELDERLY JAPANESE; DISEASE; IMPACT; RISK; GLUCOSE; COHORT; COGNITION; PEOPLE; Diabetes mellitus; Gray matter volume; Impaired fasting glucose; Impaired glucose tolerance; Oral glucose tolerance test; Prediabetes |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:19 |
| Last Modified: | 15 Feb 2019 08:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1777 |
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