Morsczeck, Christian and Reichert, Torsten E. (2017) The dexamethasone induced osteogenic differentiation of dental follicle cells. HISTOLOGY AND HISTOPATHOLOGY, 32 (12). pp. 1223-1229. ISSN 0213-3911, 1699-5848
Full text not available from this repository. (Request a copy)Abstract
Mesenchymal stem cells are excellent for in vitro studies about biological processes during the differentiation of osteogenic progenitor cells into mineralizing cells such as osteoblasts. Human dental follicle cells (DFCs) are dental mesenchymal stem cells and they can be isolated from third molar teeth. Because DFCs are the genuine progenitor cells of periodontal tissue cells, they have been used for the evaluation of molecular mechanisms during the differentiation of undifferentiated stem cells into alveolar osteoblasts and cementoblasts. To reveal molecular mechanisms of osteogenic differentiation, initial studies investigated the proteome and the transcriptome of DFCs after the induction of the osteogenic differentiation with the glucocorticoid dexamethasone. These studies showed for example that dexamethasone induces the transcription factor ZBTB16 (zinc finger and BTB domain containing protein 16) and that ZBTB16 is crucial for osteogenic differentiation of DFCs. This article is a survey of the molecular mechanisms in DFCs during osteogenic differentiation with dexamethasone.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HORMONE-RELATED PROTEIN; MESENCHYMAL STEM-CELLS; ACUTE LYMPHOBLASTIC-LEUKEMIA; PRECURSOR CELLS; GENE-EXPRESSION; IN-VITRO; TRANSCRIPTIONAL REGULATION; SKELETAL DEVELOPMENT; INDIAN HEDGEHOG; PATHWAY; Dental follicle cells; Osteogenic differentiation; Transcription factors; Signaling pathways; Periodontium |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Dec 2018 13:19 |
| Last Modified: | 10 Sep 2020 09:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1817 |
Actions (login required)
 |
View Item |
