Wilck, Nicola and Matus, Mariana G. and Kearney, Sean M. and Olesen, Scott W. and Forslund, Kristoffer and Bartolomaeus, Hendrik and Haase, Stefanie and Maehler, Anja and Balogh, Andras and Marko, Lajos and Vedenskaya, Olga V. and Kleiner, Friedrich H. and Tsvetkov, Dmitry and Klug, Lars and Costea, Paul I. and Sunagawa, Shinichi and Maier, Lisa and Rakova, Natalia and Schatz, Valentin and Neubert, Patrick and Fraetzer, Christian and Krannich, Alexander and Gollasch, Maik and Grohme, Diana A. and Corte-Real, Beatriz F. and Gerlach, Roman G. and Basic, Marijana and Typas, Athanasios and Wu, Chuan and Titze, Jens M. and Jantsch, Jonathan and Boschmann, Michael and Dechend, Ralf and Kleinewietfeld, Markus and Kempa, Stefan and Bork, Peer and Linker, Ralf A. and Alm, Eric J. and Mueller, Dominik N. (2017) Salt-responsive gut commensal modulates T(H)17 axis and disease. NATURE, 551 (7682). 585-+. ISSN 0028-0836, 1476-4687
Full text not available from this repository. (Request a copy)Abstract
A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular disease. High salt may additionally drive autoimmunity by inducing T helper 17 (T(H)17) cells, which can also contribute to hypertension. Induction of T(H)17 cells depends on gut microbiota; however, the effect of salt on the gut microbiome is unknown. Here we show that high salt intake affects the gut microbiome in mice, particularly by depleting Lactobacillus murinus. Consequently, treatment of mice with L. murinus prevented salt-induced aggravation of actively induced experimental autoimmune encephalomyelitis and salt-sensitive hypertension by modulating T(H)17 cells. In line with these findings, a moderate high-salt challenge in a pilot study in humans reduced intestinal survival of Lactobacillus spp., increased T(H)17 cells and increased blood pressure. Our results connect high salt intake to the gut-immune axis and highlight the gut microbiome as a potential therapeutic target to counteract salt-sensitive conditions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | II-INDUCED HYPERTENSION; ARYL-HYDROCARBON RECEPTOR; BLOOD-PRESSURE; MULTIPLE-SCLEROSIS; VASCULAR DYSFUNCTION; SODIUM-INTAKE; MARKER GENES; T-CELLS; MICROBIOTA; LACTOBACILLI; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:19 |
| Last Modified: | 25 Feb 2019 14:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1824 |
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